Protein detail
PPIP1
Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)
Entry name PPIP1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (6)
CD2BP1CD2BP1LCD2BP1SH-PIPPAPASPSTPIP
Gene Description
Proline-serine-threonine phosphatase interacting protein 1
Chromosome
15
Position
76993359-77037475
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyte
Function & Pathway7
Protein Function (3)
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Predicted intracellular proteins
Cellular Component (9)
Molecular Function (3)
Biological Process (3)
Reactome (7)
- R-hsa-5663205 infectious disease
- R-hsa-622312 inflammasomes
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-168643 nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways
- R-hsa-9660826 purinergic signaling in leishmaniasis infection
- R-hsa-844456 the nlrp3 inflammasome
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence30
Enzyme-Mediated Modification (4)
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PSTPIP1 | ABL1 | P00519 | Y | 345 | phosphorylation | phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapper | phosphoELM:11163214ProtMapper:11163214HPRD:11163214KEA:11163214SIGNOR:11163214 |
| PSTPIP1 | PTPN12 | Q05209 | Y | 345 | dephosphorylation | HPRDSIGNOR | HPRD:11711533SIGNOR:11711533HPRD:11971877 |
| PSTPIP1 | PTPN12 | Q05209 | Y | 345 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:11711533 |
| PSTPIP1 | LCK | P06239 | Y | 345 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| fbar_actin_dynamics_endocytosis | intracellular_intercellular_related | HGNC | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (5)
5 records.
Protein Complex Composition (11)
11 records.
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Sequence, Structure & Domains12
Sequences
Length
416
Mass
47,591
Sequence
MMPQLQFKDAFWCRDFTAHTGYEVLLQRLLDGRKMCKDMEELLRQRAQAEERYGKELVQIARKAGGQTEINSLRASFDSLKQQMENVGSSHIQLALTLREELRSLEEFRERQKEQRKKYEAVMDRVQKSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANGHQKQVEKSQNKARQCKDSATEAERVYRQSIAQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSNQLSMQCVKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPAPVPYQNYYDREVTPLTSSPGIQPSCGMIKRFSGLLHGSPKTTSLAASAASTETLTPTPERNEGVYTAIAVQEIQGNPASPAQEYRALYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERNGQRGFVPGSYLEKL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CD2BP1L; IsoId=O43586-1; Sequence=Displayed; Name=2; Synonyms=CD2BP1S; IsoId=O43586-2; Sequence=VSP_015627
Alternative Sequence
280..309; APVPYQNYYDREVTPLTSSPGIQPSCGMIK -> GEVRLADSAAS (in isoform 2)
3D Structural Models
Turn
162..164
Helix
7..10; 20..63; 71..161; 167..257; 261..272; 410..412
Beta Strand
275..277; 363..365; 373..377; 385..390; 393..401; 404..409
3D Structure
NMR spectroscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Coiled Coil
166..212
Domain (CC)
The F-BAR domain is important for filament formation. The SH3 domain is not required for filament formation or localization to the uropod.
Domain (FT)
5..264; F-BAR; 359..416; SH3
Clinical Relevance5
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |