Protein detail
PSCA
Prostate stem cell antigen
Entry name PSCA | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Cancer-related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Prostate stem cell antigen
Protein Class (3)
Cancer-related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
lncPSCA
Gene Description
Prostate stem cell antigen
Chromosome
8
Position
142670308-142682725
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization4
Cell SpecificCytotrophoblastsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyte
Function & Pathway7
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Reactome (2)
Canonical Pathways (3)
- M46 Pid atr pathway
- M70 Pid ps1 pathway
- M129 Pid plk1 pathway
Mediation Categories (3)
Clinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence16
Ligand-Receptor Signaling (15)
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
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Sequence, Structure & Domains4
Sequences
Length
114
Mass
11,959
Sequence
MAGLALQPGTALLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNASGAHALQPAAAILALLPALGLLLWGPGQL
Domain & Motif Annotations
Domain (FT)
12..98; UPAR/Ly6
Clinical Relevance5
Disease Involvement
Cancer-related genes
Related Diseases (5)
Biomarker
Phase 1; Phase 2; Phase 1/2
Drugs (4)
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 39558134 | Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis. | No abstract available |
| 39940923 | NHERF2 as a Novel Biomarker for Distinguishing MAC Pulmonary Disease from Tuberculosis Based on Proteome Analysis of Serum Extracellular Vesicles. | No abstract available |