Protein detail

PEPL

Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)

Entry name PEPL	UniProt ID O60437	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000118898

Entrez Gene Symbol

PPL

Gene Description

Periplakin

Chromosome

Position

4882507-4960741

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04382 Cornified envelope formation

Reactome

Mediation Categories

Immune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PPL	ATM	Q13315	S	1,331	phosphorylation	KEA	KEA:17570479
PPL	PRKDC	P78527	S	1,331	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	GO_Intercell	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

17 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ANKRD22 ENDOU EVPL FCF1 KLK9 PPL SULT2B1 TREX2 TRIM29	O00204 O60437 P21128 Q14134 Q5VYY1 Q92817 Q9BQ50 Q9UKQ9 Q9Y324	0:0:0:0:0:0:0:0:0	hu.MAP2
AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP2B1 CLINT1 CLTB CLTC ETNPPL GAK GGA2 HSPA14 UBC	O14976 O43747 P09497 P0CG48 P61966 P63010 Q00610 Q0VDF9 Q10567 Q14677 Q8TBG4 Q9BXS5 Q9UJY4 Q9Y6Q5	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5961
INPPL1	O15357	2	PDB	PDB:5okoPDB:4a9cPDB:6squPDB:5okmPDB:6srrPDB:5oknPDB:3nr8
INPPL1 PPM1A PPM1B	O15357 O75688 P35813	0:0:0	hu.MAP
ATP6V1H INPPL1 MTHFR PPM1A PPM1B	O15357 O75688 P35813 P42898 Q9UI12	0:0:0:0:0	hu.MAP
ARFGAP1 HEATR5A INPPL1 PPM1A PPM1B	O15357 O75688 P35813 Q86XA9 Q8N6T3	0:0:0:0:0	hu.MAP2
ARFGAP1 INPPL1 PPM1A	O15357 P35813 Q8N6T3	0:0:0	hu.MAP2
DGCR8 INPPL1 MAPRE2 PLEK2	O15357 Q15555 Q8WYQ5 Q9NYT0	0:0:0:0	Havugimana2012	Havugimana2012:C_294
ANP32A BRD8 DMAP1 ETNPPL H2AZ2 KAT5 MORF4L1 RUVBL1 RUVBL2 TRRAP TTI1 YEATS4	O43156 O95619 P39687 Q71UI9 Q8TBG4 Q92993 Q9H0E9 Q9NPF5 Q9UBU8 Q9Y230 Q9Y265 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4533
PPL	O60437	4	PDB	PDB:4q28

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometryR Sequencing	1	28396511

Sequence, Structure & Domains

Sequences

Length

1,756

Mass

204,747

Sequence

MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRRSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK

3D Structural Models

Turn

1663..1665; 1713..1716

Helix

1671..1676; 1682..1689; 1722..1726; 1732..1739; 1745..1753

Beta Strand

1655..1661; 1693..1701; 1706..1712; 1717..1721

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Repeat

216..317; Spectrin 1; 323..485; Spectrin 2; 505..612; Spectrin 3; 733..861; Spectrin 4; 1651..1685; Plectin 1; 1700..1735; Plectin 2

Coiled Coil

16..125; 188..389; 585..820; 886..1645

Domain (FT)

399..455; SH3

Region

1557..1756; Interacts with BFSP2 and VIM

Protein Families

Plakin or cytolinker family

Sequence Similarities

Belongs to the plakin or cytolinker family.

Clinical Relevance

Antibody

HPA042550 HPA059859

Interaction Protein

ENSG00000017797ENSG00000026025ENSG00000142208

Interaction Count

Interaction Dataset

intact_biogrid