Protein detail
MOT2
Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)
Entry name MOT2 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
16..36; Helical; Name=1; 60..80; Helical; Name=2; 90..110; Helical; Name=3; 116..136; Helical; Name=4; 149..169; Helical; Name=5; 174..194; Helical; Name=6; 247..267; Helical; Name=7; 283..303; Helical; Name=8; 313..333; Helical; Name=9; 339..359; Helical; Name=10; 374..394; Helical; Name=11; 407..427; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
MCT2
Gene Description
Solute carrier family 16 member 7
Chromosome
12
Position
59596029-59789855
Supporting publications (n)
1
EVMP confidence score
0.40
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (9)
- GO:0005654 nucleoplasm
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0016323 basolateral plasma membrane
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0098686 hippocampal mossy fiber to CA3 synapse
- GO:0098688 parallel fiber to Purkinje cell synapse
- GO:0098839 postsynaptic density membrane
- GO:0098978 glutamatergic synapse
Molecular Function (6)
Biological Process (3)
Reactome (4)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence29
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| slc | transporter | Surfaceome | Yes | ||||
| transporter | transporter | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | TopDB | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| basolateral_cell_membrane | plasma_membrane | UniProt_location |
Protein Complex Composition (1)
Sequence, Structure & Domains
Sequences
Length
478
Mass
52,200
Sequence
MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Compositional Bias
437..461; Basic and acidic residues
Region
200..224; Disordered; 437..478; Disordered
Protein Families (2)
- Major facilitator superfamily
- Monocarboxylate porter (TC 2.A.1.13) family
Sequence Similarities
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Clinical Relevance
Drugs
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37427430 | Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis. | No related sentences available |