Protein detail

MOT2

Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)

Entry name MOT2	UniProt ID O60669	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 12	Protein classification Metabolic proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)

Protein Class (3)

Metabolic proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

16..36; Helical; Name=1; 60..80; Helical; Name=2; 90..110; Helical; Name=3; 116..136; Helical; Name=4; 149..169; Helical; Name=5; 174..194; Helical; Name=6; 247..267; Helical; Name=7; 283..303; Helical; Name=8; 313..333; Helical; Name=9; 339..359; Helical; Name=10; 374..394; Helical; Name=11; 407..427; Helical; Name=12

Transmembrane Count

Ensembl

ENSG00000118596

Entrez Gene Symbol

SLC16A7

Gene Synonym

MCT2

Gene Description

Solute carrier family 16 member 7

Chromosome

Position

59596029-59789855

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway6

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component (9)

Molecular Function (6)

Biological Process (3)

Reactome (4)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence29

Ligand-Receptor Signaling (27)

27 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
receptor	receptor	connectomeDB2020	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLC16A7	O60669	2	PDB	PDB:7bp3

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	4	27894104 29687628 39558134 29148239

Sequence, Structure & Domains8

Sequences

Length

478

Mass

52,200

Sequence

MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

437..461; Basic and acidic residues

Region

200..224; Disordered; 437..478; Disordered

Protein Families (2)

Major facilitator superfamily
Monocarboxylate porter (TC 2.A.1.13) family

Sequence Similarities

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Clinical Relevance2

Drugs

METHOTREXATE

Antibody

HPA005911

Supporting Publications1

PMID	Title	Abstract
37427430	Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.	No abstract available