Protein detail

S19A2

Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1)

Entry name S19A2	UniProt ID O60779	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 12	Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1)

Protein Class (6)

Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (6)

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Human disease related genes:Cardiovascular diseases:Hematologic diseases
Potential drug targets
Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
Transporters:Electrochemical Potential-driven transporters
Disease related genes

Transmembrane

29..46; Helical; 73..91; Helical; 100..118; Helical; 129..149; Helical; 166..185; Helical; 192..208; Helical; 286..310; Helical; 338..354; Helical; 364..380; Helical; 387..409; Helical; 420..443; Helical; 456..479; Helical

Transmembrane Count

Ensembl

ENSG00000117479

Entrez Gene Symbol

SLC19A2

Gene Synonym (3)

ThT1THTR1TRMA

Gene Description

Solute carrier family 19 member 2

Chromosome

Position

169463909-169485944

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue Specificchoroid plexusCell SpecificBrain excitatory neurons

Function & Pathway7

Protein Function (6)

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Human disease related genes:Cardiovascular diseases:Hematologic diseases
Potential drug targets
Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
Transporters:Electrochemical Potential-driven transporters
Disease related genes

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04977 Vitamin digestion and absorption

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence24

Ligand-Receptor Signaling (23)

23 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometry	2	30646616 38321535

Sequence, Structure & Domains11

Sequences

Length

497

Mass

55,400

Sequence

MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSSQVTTS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60779-1; Sequence=Displayed; Name=2; IsoId=O60779-2; Sequence=VSP_036467

Alternative Sequence

69..269; Missing (in isoform 2)

3D Structural Models

Turn

48..52; 60..62; 95..97; 445..448

Helix

32..45; 54..57; 66..94; 99..116; 122..135; 138..144; 145..147; 154..181; 187..205; 279..288; 293..296; 299..323; 333..351; 358..382; 386..414; 417..419; 420..442; 452..482

Beta Strand

290..292; 326..329

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Protein Families

Reduced folate carrier (RFC) transporter (TC 2.A.48) family

Sequence Similarities

Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.

Clinical Relevance5

Disease Involvement (3)

DeafnessDiabetes mellitusDisease variant

Antibody (2)

HPA006119 HPA016599

Interaction Protein (4)

ENSG00000137216ENSG00000143418ENSG00000149218ENSG00000154723

Interaction Count

Interaction Dataset (4)

biogrid_opencellintact_biogridintact_biogrid_bioplexbiogrid_bioplex

Supporting Publications2

PMID	Title	Abstract
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available