Protein detail
S19A2
Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1)
Protein symbol S19A2 | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Transmembrane
29..46; Helical; 73..91; Helical; 100..118; Helical; 129..149; Helical; 166..185; Helical; 192..208; Helical; 286..310; Helical; 338..354; Helical; 364..380; Helical; 387..409; Helical; 420..443; Helical; 456..479; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
ThT1THTR1TRMA
Gene Description
Solute carrier family 19 member 2
Chromosome
1
Position
169463909-169485944
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificchoroid plexusCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
497
Mass
55,400
Sequence
MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSSQVTTS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60779-1; Sequence=Displayed; Name=2; IsoId=O60779-2; Sequence=VSP_036467
Alternative Sequence
69..269; Missing (in isoform 2)
3D Structural Models
Turn
48..52; 60..62; 95..97; 445..448
Helix
32..45; 54..57; 66..94; 99..116; 122..135; 138..144; 145..147; 154..181; 187..205; 279..288; 293..296; 299..323; 333..351; 358..382; 386..414; 417..419; 420..442; 452..482
Beta Strand
290..292; 326..329
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Protein Families
Reduced folate carrier (RFC) transporter (TC 2.A.48) family
Sequence Similarities
Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.