Protein detail

S19A2

Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1)

Entry name
S19A2
UniProt ID
O60779
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
12
Protein classification
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (6)
  • Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Potential drug targets
  • Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
Transmembrane
29..46; Helical; 73..91; Helical; 100..118; Helical; 129..149; Helical; 166..185; Helical; 192..208; Helical; 286..310; Helical; 338..354; Helical; 364..380; Helical; 387..409; Helical; 420..443; Helical; 456..479; Helical
Transmembrane Count
12
Ensembl
ENSG00000117479
Entrez Gene Symbol
SLC19A2
Gene Synonym (3)
ThT1THTR1TRMA
Gene Description
Solute carrier family 19 member 2
Chromosome
1
Position
169463909-169485944
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificchoroid plexusCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function (6)
  • Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Potential drug targets
  • Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
KEGG
hsa04977 Vitamin digestion and absorption
Reactome (3)
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence24

Ligand-Receptor Signaling (23)

23 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
cell_surfacecell_surfaceOmniPath
receptorreceptorscConnectYes
transmembranetransmembrane_predictedPhobius
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyWestern blottingFlow cytometry23064661638321535
Sequence, Structure & Domains

Sequences

Length
497
Mass
55,400
Sequence
MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSSQVTTS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60779-1; Sequence=Displayed; Name=2; IsoId=O60779-2; Sequence=VSP_036467
Alternative Sequence
69..269; Missing (in isoform 2)

3D Structural Models

Turn
48..52; 60..62; 95..97; 445..448
Helix
32..45; 54..57; 66..94; 99..116; 122..135; 138..144; 145..147; 154..181; 187..205; 279..288; 293..296; 299..323; 333..351; 358..382; 386..414; 417..419; 420..442; 452..482
Beta Strand
290..292; 326..329
3D Structure
Electron microscopy (2)

Domain & Motif Annotations

Protein Families
Reduced folate carrier (RFC) transporter (TC 2.A.48) family
Sequence Similarities
Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
Clinical Relevance
Disease Involvement (3)
DeafnessDiabetes mellitusDisease variant
Related Diseases (2)
DeafnessDiabetes mellitus
Antibody (2)
HPA006119HPA016599
Interaction Protein (4)
ENSG00000137216ENSG00000143418ENSG00000149218ENSG00000154723
Interaction Count
4
Interaction Dataset (4)
biogrid_opencellintact_biogridintact_biogrid_bioplexbiogrid_bioplex
Supporting Publications2
PMIDTitleRelated sentences
38207106Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.No related sentences available
40189497Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.No related sentences available