Protein detail
CUTA
Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor)
Protein symbol CUTA | UniProt ID | EVMP score 0.60 |
Frequency 13 | Transmembrane count | Protein classification Predicted intracellular proteinsPredicted secreted proteins |
Basic Information
Protein Names
Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor)
Protein Class
Predicted intracellular proteinsPredicted secreted proteins
Protein Function
- Predicted secreted proteins
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ACHAPC6orf82
Gene Description
CutA divalent cation tolerance homolog
Chromosome
6
Position
33416442-33418317
Frequency
13
EVMP Score
0.60
Fluorescence & Localization
Cell SpecificEarly primary spermatocytes
Function & Pathway
Protein Function
- Predicted secreted proteins
- Predicted intracellular proteins
Biological Process
Canonical Pathways
M276 Pid fgf pathway
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | Yes | No | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | No | No |
| transmembrane | transmembrane | LOCATE | No | No | Yes | No | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CUTA | O60888 | 6 | PDB | PDB:1xk8PDB:2zfh | ||
| ACSL5CUTAECHS1HADHHSD17B10UPP1 | O60888P30084Q16831Q16836Q99714Q9ULC5 | 0:0:0:0:0:0 | hu.MAP2 | |||
| CUTAUPP1 | O60888Q16831 | 0:0 | hu.MAP2 | |||
| ACSL5CUTAHADHHSD17B10PGM2L1UPP1 | O60888Q16831Q16836Q6PCE3Q99714Q9ULC5 | 0:0:0:0:0:0 | hu.MAP2 | |||
| CUTAPGM2L1UPP1 | O60888Q16831Q6PCE3 | 0:0:0 | hu.MAP2 | |||
| CDK19CUTAFKBP15GPN1MYEF2 | O60888Q5T1M5Q9BWU1Q9HCN4Q9P2K5 | 0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_466 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31805958 |
Sequence, Structure & Domains
Sequences
Length
179
Mass
19,116
Sequence
MSGGRAPAVLLGGVASLLLSFVWMPALLPVASRLLLLPRVLLTMASGSPPTQPSPASDSGSGYVPGSVSAAFVTCPNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIALPVEQGNFPYLQWVRQVTESVSDSITVLP
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=B; IsoId=O60888-1; Sequence=Displayed; Name=A; IsoId=O60888-2; Sequence=VSP_013225; Name=C; IsoId=O60888-3; Sequence=VSP_013226
Alternative Sequence
1..23; Missing (in isoform C); 1..14; MSGGRAPAVLLGGV -> MIGSGLAGSGGAGGPSSTVTWCALFSNHVAATQ (in isoform A)
3D Structural Models
Helix
78..90; 127..129; 130..140; 158..166
Beta Strand
67..77; 95..109; 112..126; 142..145; 148..153
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Region
168..176; O-glycosylated at one site
Protein Families
CutA family
Sequence Similarities
Belongs to the CutA family.