Protein detail

CUTA

Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor)

Entry name CUTA	UniProt ID O60888	EVMP confidence score 0.72
Supporting publications (n) 13	Transmembrane count	Protein classification Predicted intracellular proteinsPredicted secreted proteins

Basic Information

Protein Names

Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor)

Protein Class (2)

Predicted intracellular proteinsPredicted secreted proteins

Protein Function (2)

Predicted secreted proteins
Predicted intracellular proteins

Ensembl

ENSG00000112514

Entrez Gene Symbol

CUTA

Gene Synonym (2)

ACHAPC6orf82

Gene Description

CutA divalent cation tolerance homolog

Chromosome

Position

33416442-33418317

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization

Cell SpecificEarly primary spermatocytes

Function & Pathway

Protein Function (2)

Predicted secreted proteins
Predicted intracellular proteins

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

Canonical Pathways

M276 Pid fgf pathway

Mediation Categories

Other mediation

Relations & Evidence19

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_phobius	transmembrane_predicted	Almen2009			Yes
transmembrane_tmhmm	transmembrane_predicted	Almen2009			Yes

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Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CUTA	O60888	6	PDB	PDB:1xk8PDB:2zfh
ACSL5 CUTA ECHS1 HADH HSD17B10 UPP1	O60888 P30084 Q16831 Q16836 Q99714 Q9ULC5	0:0:0:0:0:0	hu.MAP2
CUTA UPP1	O60888 Q16831	0:0	hu.MAP2
ACSL5 CUTA HADH HSD17B10 PGM2L1 UPP1	O60888 Q16831 Q16836 Q6PCE3 Q99714 Q9ULC5	0:0:0:0:0:0	hu.MAP2
CUTA PGM2L1 UPP1	O60888 Q16831 Q6PCE3	0:0:0	hu.MAP2
CDK19 CUTA FKBP15 GPN1 MYEF2	O60888 Q5T1M5 Q9BWU1 Q9HCN4 Q9P2K5	0:0:0:0:0	Havugimana2012	Havugimana2012:C_466

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	31805958

Sequence, Structure & Domains

Sequences

Length

179

Mass

19,116

Sequence

MSGGRAPAVLLGGVASLLLSFVWMPALLPVASRLLLLPRVLLTMASGSPPTQPSPASDSGSGYVPGSVSAAFVTCPNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIALPVEQGNFPYLQWVRQVTESVSDSITVLP

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=B; IsoId=O60888-1; Sequence=Displayed; Name=A; IsoId=O60888-2; Sequence=VSP_013225; Name=C; IsoId=O60888-3; Sequence=VSP_013226

Alternative Sequence

1..23; Missing (in isoform C); 1..14; MSGGRAPAVLLGGV -> MIGSGLAGSGGAGGPSSTVTWCALFSNHVAATQ (in isoform A)

3D Structural Models

Helix

78..90; 127..129; 130..140; 158..166

Beta Strand

67..77; 95..109; 112..126; 142..145; 148..153

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Region

168..176; O-glycosylated at one site

Protein Families

CutA family

Sequence Similarities

Belongs to the CutA family.

Clinical Relevance

Antibody (3)

CAB016787 HPA064369 HPA070199

Interaction Protein

ENSG00000162458

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications13

PMID	Title	Related sentences
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No related sentences available
41128489	Multiparametric Bulk and Single Extracellular Vesicle Pipeline for Identifying Adipose-Specific Signatures in Matched Human Biospecimens.	No related sentences available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No related sentences available

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