Protein detail

RAMP3

Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)

Entry name RAMP3	UniProt ID O60896	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)

Protein Function

FDA approved drug targets:Small molecule drugs
Transporters:Accessory Factors Involved in Transport

Transmembrane

114..138; Helical

Transmembrane Count

Ensembl

ENSG00000122679

Entrez Gene Symbol

RAMP3

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificEsophageal apical cells

Function & Pathway

Protein Function

FDA approved drug targets:Small molecule drugs
Transporters:Accessory Factors Involved in Transport

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M33 Pid glypican 1pathway
M252 Pid il8 cxcr1 pathway
M76 Pid p38 alpha beta pathway

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

52 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
other_receptor_family	receptor	HPMR	No	Yes	No	Yes	No
ramp	receptor	HPMR	No	Yes	No	Yes	No
ramp	receptor	Surfaceome	No	Yes	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
AMY3_receptor	CALCR RAMP3	O60896 P30988	1:1	CellPhoneDBCellChatDBComplexPortalGuide2Pharma	CellPhoneDB:AMY3_receptorintact:EBI-9685439	12565884 15692146 14722252 11033437 14755292 21658025 24169554

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blottingELISA	2	38731868 40311616

Sequence, Structure & Domains

Sequences

Length

148

Mass

16,518

Sequence

METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL

3D Structural Models

Turn

141..143

Helix

30..47; 53..56; 59..79; 87..100; 116..119; 121..140

Beta Strand

101..103

3D Structure

Electron microscopy (7)

Domain & Motif Annotations

Protein Families

RAMP family

Sequence Similarities

Belongs to the RAMP family.

Clinical Relevance

Drugs

PRAMLINTIDE PRAMLINTIDE ACETATE STREPTOZOCIN