Protein detail

RAMP3

Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)

Entry name RAMP3	UniProt ID O60896	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)

Protein Function (2)

FDA approved drug targets:Small molecule drugs
Transporters:Accessory Factors Involved in Transport

Transmembrane

114..138; Helical

Transmembrane Count

Ensembl

ENSG00000122679

Entrez Gene Symbol

RAMP3

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificEsophageal apical cells

Function & Pathway8

Protein Function (2)

FDA approved drug targets:Small molecule drugs
Transporters:Accessory Factors Involved in Transport

Cellular Component (6)

Molecular Function (5)

Biological Process (3)

KEGG (2)

Reactome (5)

Canonical Pathways (3)

M33 Pid glypican 1pathway
M252 Pid il8 cxcr1 pathway
M76 Pid p38 alpha beta pathway

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence54

Ligand-Receptor Signaling (52)

52 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
receptor_activity_modifying	receptor_regulator	Almen2009	Yes	No	No	Yes	No
receptor_regulator	receptor_regulator	OmniPath	Yes	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
AMY3_receptor	CALCR RAMP3	O60896 P30988	1:1	CellPhoneDBCellChatDBComplexPortalGuide2Pharma	CellPhoneDB:AMY3_receptorintact:EBI-9685439	12565884 15692146 14722252 11033437 14755292 21658025 24169554

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blottingELISA	2	38731868 40311616

Sequence, Structure & Domains9

Sequences

Length

148

Mass

16,518

Sequence

METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL

3D Structural Models

Turn

141..143

Helix

30..47; 53..56; 59..79; 87..100; 116..119; 121..140

Beta Strand

101..103

3D Structure

Electron microscopy (7)

Domain & Motif Annotations

Protein Families

RAMP family

Sequence Similarities

Belongs to the RAMP family.

Clinical Relevance1

Drugs (3)

PRAMLINTIDE PRAMLINTIDE ACETATE STREPTOZOCIN

Supporting Publications1

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available