Protein detail

PFD1

Prefoldin subunit 1

Entry name PFD1	UniProt ID O60925	EVMP confidence score 0.75
Supporting publications (n) 43	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Prefoldin subunit 1

Protein Class (3)

Essential proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000113068

Entrez Gene Symbol

PFDN1

Gene Synonym

PFD1

Gene Description

Prefoldin subunit 1

Chromosome

Position

140245035-140303113

Supporting publications (n)

EVMP confidence score

0.75

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificEndometrial luminal cells

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

Reactome (2)

Mediation Categories

Metabolism mediation

Relations & Evidence14

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (10)

10 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Prefoldin co-chaperone	PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 VBP1	O15212 O60925 P61758 Q99471 Q9NQP4 Q9UHV9	1:1:1:1:1:1	SIGNORCORUMComplexPortalCompleathu.MAP2	SIGNOR:SIGNOR-C513Compleat:HC72CORUM:33intact:EBI-25825106	31738558 9463374 12456645 14634002 14755292 32699605
Prefoldin co-chaperone complex	PDRG1 PFDN1 PFDN2 PFDN5 PFDN6 VBP1	O15212 O60925 P61758 Q99471 Q9NUG6 Q9UHV9	1:1:1:1:1:1	ComplexPortal		34761191 14755292 38498526 38532014 32699605
prefoldin complex	PDRG1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 SLMAP URI1 UXT VBP1	O15212 O60925 O94763 P61758 Q14BN4 Q99471 Q9NQP4 Q9NUG6 Q9UBK9 Q9UHV9	1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC11	9630229
	DNAAF10 MARCHF9 PDRG1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 PIH1D1 RPAP3 TIPARP URI1 UXT VBP1	O15212 O60925 O94763 P61758 Q7Z3E1 Q86YJ5 Q96MX6 Q99471 Q9H6T3 Q9NQP4 Q9NUG6 Q9NWS0 Q9UBK9 Q9UHV9	0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	ABL1 NUBP2 PDRG1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 PPP1R14B VBP1	O15212 O60925 P00519 P61758 Q96C90 Q99471 Q9NQP4 Q9NUG6 Q9UHV9 Q9Y5Y2	0:0:0:0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_586
	CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TCP1 VBP1	O15212 O60925 P17987 P40227 P48643 P49368 P50990 P50991 P61758 P78371 Q99471 Q99832 Q9NQP4 Q9UHV9	1:1:2:2:2:2:2:2:1:2:1:2:1:1	PDB	PDB:6nr8PDB:6nrbPDB:7wu7PDB:6nrcPDB:6nr9PDB:6nrd
	AOX1 LMNB2 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 VBP1	O15212 O60925 P61758 Q03252 Q06278 Q99471 Q9NQP4 Q9UHV9	0:0:0:0:0:0:0:0	hu.MAP
	MARCHF9 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TIPARP VBP1	O15212 O60925 P61758 Q7Z3E1 Q86YJ5 Q99471 Q9NQP4 Q9UHV9	0:0:0:0:0:0:0:0	hu.MAP2
	AOX1 LMNB2 PFDN1 PFDN4 PFDN5 PFDN6	O15212 O60925 Q03252 Q06278 Q99471 Q9NQP4	0:0:0:0:0:0	hu.MAP
	MEF2C MEF2D PFDN1 SNX5 USF2	O60925 Q06413 Q14814 Q15853 Q9Y5X3	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8682

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	28986585

Sequence, Structure & Domains6

Sequences

Length

122

Mass

14,210

Sequence

MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHSQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ

3D Structural Models

3D Structure

Electron microscopy (6)

Domain & Motif Annotations

Protein Families

Prefoldin subunit beta family

Sequence Similarities

Belongs to the prefoldin subunit beta family.

Clinical Relevance4

Antibody

HPA006499

Interaction Protein (11)

ENSG00000101132ENSG00000108262ENSG00000123349ENSG00000131653ENSG00000132305ENSG00000140395ENSG00000140854ENSG00000143256ENSG00000155959ENSG00000172354ENSG00000204220

Interaction Count

Interaction Dataset (4)

biogrid_bioplexintact_biogridintact_biogrid_bioplexbiogrid_opencell_bioplex

Supporting Publications43

PMID	Title	Abstract
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
38644352	The tumour-derived extracellular vesicle proteome varies by endometrial cancer histology and is confounded by an obesogenic environment.	No abstract available
39409015	SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy.	No abstract available
39766158	A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis.	No abstract available
39873726	Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer.	No abstract available
39940641	Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients.	No abstract available
39949490	CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro.	No abstract available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No abstract available
40311616	Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer.	No abstract available
40545963	Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple-Negative Breast Cancer.	No abstract available

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