Protein detail

WDR1

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Entry name WDR1	UniProt ID O75083	EVMP confidence score 0.75
Supporting publications (n) 50	Transmembrane count	Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Protein Class (5)

Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Ensembl

ENSG00000071127

Entrez Gene Symbol

WDR1

Gene Synonym

AIP1

Gene Description

WD repeat domain 1

Chromosome

Position

10068089-10116972

Supporting publications (n)

EVMP confidence score

0.75

Fluorescence & Localization7

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilSecretome LocationSecreted to bloodSecretome FunctionImmunity

Function & Pathway6

Protein Function (3)

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Cellular Component (10)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence65

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (56)

56 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
5FMC (Friends of Methylated Chtop) complex	LAS1L PELP1 SENP3 TEX10 WDR18	Q8IZL8 Q9BV38 Q9H4L4 Q9NXF1 Q9Y4W2	0:0:0:0:0	CORUM	CORUM:6854	22872859
DDX27-PeBoW complex	BOP1 DDX27 PES1 WDR12	O00541 Q14137 Q96GQ7 Q9GZL7	0:0:0:0	CORUM	CORUM:6306	25825154
HT_DM_Cluster212	BRWD1 BRWD3 DDB1 DTL PHIP WDR17	Q16531 Q6RI45 Q8IZU2 Q8WWQ0 Q9NSI6 Q9NZJ0	1:1:1:1:1:1	Compleat	Compleat:HC3530	22036573
HT_DM_Cluster38	BOP1 EIF6 GTPBP4 MAK16 MRPL2 PES1 RRP1 RRP1B WDR12 WDR74	O00541 P56182 P56537 Q14137 Q14684 Q5T653 Q6RFH5 Q9BXY0 Q9BZE4 Q9GZL7	1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2477	22036573
Intraflagellar transport complex A	IFT122 IFT140 IFT43 TTC21B WDR19 WDR35	Q7Z4L5 Q8NEZ3 Q96FT9 Q96RY7 Q9HBG6 Q9P2L0	1:1:1:1:1:1	ComplexPortalPDB	PDB:8fgwintact:EBI-22224236PDB:8bbg	27806291 23945166 29272450 14755292 26498262 22118932
Intraflagellar transport complex A	IFT122 IFT140 TTC21B WDR19 WDR35	Q7Z4L5 Q8NEZ3 Q96RY7 Q9HBG6 Q9P2L0	0:0:0:0:0	CORUM	CORUM:6585	20889716
LAS1L-PELP1-TEX10-WDR18-NOL9-SENP3 complex	LAS1L NOL9 PELP1 SENP3 TEX10 WDR18	Q5SY16 Q8IZL8 Q9BV38 Q9H4L4 Q9NXF1 Q9Y4W2	0:0:0:0:0:0	CORUMhu.MAPhu.MAP2	CORUM:6855	22190735
PELP1-TEX10-WDR18 complex	PELP1 TEX10 WDR18	Q8IZL8 Q9BV38 Q9NXF1	2:2:2	CORUMhu.MAP2PDB	CORUM:6857PDB:9dum	21326211
PeBoW complex	BOP1 PES1 WDR12	O00541 Q14137 Q9GZL7	1:1:1	CORUMComplexPortalCompleathu.MAP2CFinder	intact:EBI-9026844CORUM:6856Compleat:HC3045Compleat:HC1392	16043514 14755292 12110181 24120868 17353269
Rix1 complex	NOL9 PELP1 SENP3 TEX10 WDR18	Q5SY16 Q8IZL8 Q9BV38 Q9H4L4 Q9NXF1	0:0:0:0:0	SIGNOR	SIGNOR:SIGNOR-C373

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38071653

Sequence, Structure & Domains8

Sequences

Length

606

Mass

66,194

Sequence

MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75083-1; Sequence=Displayed; Name=2; IsoId=O75083-3; Sequence=VSP_012926

Alternative Sequence

47..186; Missing (in isoform 2)

Domain & Motif Annotations

Repeat

4..45; WD 1; 48..87; WD 2; 93..135; WD 3; 138..176; WD 4; 180..218; WD 5; 224..263; WD 6; 270..306; WD 7; 311..351; WD 8; 358..408; WD 9; 432..474; WD 10; 480..518; WD 11; 523..561; WD 12; 566..604; WD 13

Protein Families

WD repeat AIP1 family

Sequence Similarities

Belongs to the WD repeat AIP1 family.

Clinical Relevance5

Disease Involvement

Disease variant

Antibody (3)

CAB020804 HPA036434 HPA070293

Interaction Protein (2)

ENSG00000075624ENSG00000184009

Interaction Count

Interaction Dataset (2)

intact_biogrid_opencellbiogrid_opencell

Supporting Publications49

PMID	Title	Abstract
25755179	Urinary extracellular vesicles as reservoirs of altered proteins during the pathogenesis of polycystic kidney disease.	No abstract available
26826536	[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].	No abstract available
27086912	Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein.	No abstract available
27821849	Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.	No abstract available
28680152	Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity.	No abstract available
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available
31382537	An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers.	No abstract available
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
32230970	Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.	No abstract available
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available

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