Protein detail
WDR1
WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)
Protein symbol WDR1 | UniProt ID | EVMP score 0.75 |
Frequency 50 | Transmembrane count | Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)
Protein Class
Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
AIP1
Gene Description
WD repeat domain 1
Chromosome
4
Position
10068089-10116972
Frequency
50
EVMP Score
0.75
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilSecretome LocationSecreted to bloodSecretome FunctionImmunity
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
56 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| 5FMC (Friends of Methylated Chtop) complex | LAS1LPELP1SENP3TEX10WDR18 | Q8IZL8Q9BV38Q9H4L4Q9NXF1Q9Y4W2 | 0:0:0:0:0 | CORUM | CORUM:6854 | 22872859 |
| DDX27-PeBoW complex | BOP1DDX27PES1WDR12 | O00541Q14137Q96GQ7Q9GZL7 | 0:0:0:0 | CORUM | CORUM:6306 | 25825154 |
| HT_DM_Cluster212 | BRWD1BRWD3DDB1DTLPHIPWDR17 | Q16531Q6RI45Q8IZU2Q8WWQ0Q9NSI6Q9NZJ0 | 1:1:1:1:1:1 | Compleat | Compleat:HC3530 | 22036573 |
| HT_DM_Cluster38 | BOP1EIF6GTPBP4MAK16MRPL2PES1RRP1RRP1BWDR12WDR74 | O00541P56182P56537Q14137Q14684Q5T653Q6RFH5Q9BXY0Q9BZE4Q9GZL7 | 1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC2477 | 22036573 |
| Intraflagellar transport complex A | IFT122IFT140IFT43TTC21BWDR19WDR35 | Q7Z4L5Q8NEZ3Q96FT9Q96RY7Q9HBG6Q9P2L0 | 1:1:1:1:1:1 | ComplexPortalPDB | PDB:8fgwintact:EBI-22224236PDB:8bbg | 278062912394516629272450147552922649826222118932 |
| Intraflagellar transport complex A | IFT122IFT140TTC21BWDR19WDR35 | Q7Z4L5Q8NEZ3Q96RY7Q9HBG6Q9P2L0 | 0:0:0:0:0 | CORUM | CORUM:6585 | 20889716 |
| LAS1L-PELP1-TEX10-WDR18-NOL9-SENP3 complex | LAS1LNOL9PELP1SENP3TEX10WDR18 | Q5SY16Q8IZL8Q9BV38Q9H4L4Q9NXF1Q9Y4W2 | 0:0:0:0:0:0 | CORUMhu.MAPhu.MAP2 | CORUM:6855 | 22190735 |
| PELP1-TEX10-WDR18 complex | PELP1TEX10WDR18 | Q8IZL8Q9BV38Q9NXF1 | 2:2:2 | CORUMhu.MAP2PDB | CORUM:6857PDB:9dum | 21326211 |
| PeBoW complex | BOP1PES1WDR12 | O00541Q14137Q9GZL7 | 1:1:1 | CORUMComplexPortalCompleathu.MAP2CFinder | intact:EBI-9026844CORUM:6856Compleat:HC3045Compleat:HC1392 | 1604351414755292121101812412086817353269 |
| Rix1 complex | NOL9PELP1SENP3TEX10WDR18 | Q5SY16Q8IZL8Q9BV38Q9H4L4Q9NXF1 | 0:0:0:0:0 | SIGNOR | SIGNOR:SIGNOR-C373 |
Page 1 of 6Next
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38071653 |
Sequence, Structure & Domains
Sequences
Length
606
Mass
66,194
Sequence
MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75083-1; Sequence=Displayed; Name=2; IsoId=O75083-3; Sequence=VSP_012926
Alternative Sequence
47..186; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Repeat
4..45; WD 1; 48..87; WD 2; 93..135; WD 3; 138..176; WD 4; 180..218; WD 5; 224..263; WD 6; 270..306; WD 7; 311..351; WD 8; 358..408; WD 9; 432..474; WD 10; 480..518; WD 11; 523..561; WD 12; 566..604; WD 13
Protein Families
WD repeat AIP1 family
Sequence Similarities
Belongs to the WD repeat AIP1 family.