Protein detail
WDR1
WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)
Entry name WDR1 | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 50 | Transmembrane count | Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)
Protein Class (5)
Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
AIP1
Gene Description
WD repeat domain 1
Chromosome
4
Position
10068089-10116972
Supporting publications (n)
50
EVMP confidence score
0.75
Fluorescence & Localization7
Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilSecretome LocationSecreted to bloodSecretome FunctionImmunity
Function & Pathway6
Protein Function (3)
- Disease related genes
- Human disease related genes:Immune system diseases:Other immune system diseases
- Predicted intracellular proteins
Cellular Component (10)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence65
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (56)
56 records.
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38071653 |
Sequence, Structure & Domains8
Sequences
Length
606
Mass
66,194
Sequence
MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75083-1; Sequence=Displayed; Name=2; IsoId=O75083-3; Sequence=VSP_012926
Alternative Sequence
47..186; Missing (in isoform 2)
Domain & Motif Annotations
Repeat
4..45; WD 1; 48..87; WD 2; 93..135; WD 3; 138..176; WD 4; 180..218; WD 5; 224..263; WD 6; 270..306; WD 7; 311..351; WD 8; 358..408; WD 9; 432..474; WD 10; 480..518; WD 11; 523..561; WD 12; 566..604; WD 13
Protein Families
WD repeat AIP1 family
Sequence Similarities
Belongs to the WD repeat AIP1 family.
Clinical Relevance5
Supporting Publications49
| PMID | Title | Abstract |
|---|---|---|
| 25755179 | Urinary extracellular vesicles as reservoirs of altered proteins during the pathogenesis of polycystic kidney disease. | No abstract available |
| 26826536 | [Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles]. | No abstract available |
| 27086912 | Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein. | No abstract available |
| 27821849 | Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation. | No abstract available |
| 28680152 | Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity. | No abstract available |
| 30915084 | Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton. | No abstract available |
| 31382537 | An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers. | No abstract available |
| 31805958 | Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment. | No abstract available |
| 32230970 | Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles. | No abstract available |
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No abstract available |
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