Protein detail

WDR1

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Entry name WDR1	UniProt ID O75083	EVMP confidence score 0.63
Supporting publications (n) 49	Transmembrane count	Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Protein Class (5)

Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Ensembl

ENSG00000071127

Entrez Gene Symbol

WDR1

Gene Synonym

AIP1

Gene Description

WD repeat domain 1

Chromosome

Position

10068089-10116972

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilSecretome LocationSecreted to bloodSecretome FunctionImmunity

Function & Pathway

Protein Function (3)

Disease related genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins

Cellular Component (10)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence65

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter
ecm	ecm	MatrixDB	Yes
ecm	ecm	OmniPath	Yes
extracellular	extracellular	OmniPath
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath

Protein Complex Composition (56)

56 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Rix1p complex	TEX10 WDR18	Q9BV38 Q9NXF1	1:1	Compleat	Compleat:HC1341	15260980
Rixosome RNA degradation complex	LAS1L MDN1 NOL9 PELP1 SENP3 TEX10 WDR18	Q5SY16 Q8IZL8 Q9BV38 Q9H4L4 Q9NU22 Q9NXF1 Q9Y4W2	1:1:1:1:1:1:1	ComplexPortal	intact:EBI-44456871PDB:7UWF	35355014 36351913 14755292 22872859
Yph1-L	BOP1 EIF6 GNL2 GNL3 GNL3L GTPBP4 PES1 RPL17 RPL23 RPL3 RPL35A RPL3L RPL4 RPL5 RPL7A RPL8 RSL1D1 RSL24D1 WDR12 WDR5 WDR5B	O00541 O76021 P18077 P18621 P36578 P39023 P46777 P56537 P61964 P62424 P62829 P62917 Q13823 Q14137 Q86VZ2 Q92901 Q9BVP2 Q9BZE4 Q9GZL7 Q9NVN8 Q9UHA3	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2923	12110181
	B3GAT3 GOLIM4 RELCH STX6 WDR13	O00461 O43752 O94766 Q9H1Z4 Q9P260	0:0:0:0:0	hu.MAP2
	B3GAT3 GOLIM4 RELCH WDR13	O00461 O94766 Q9H1Z4 Q9P260	0:0:0:0	hu.MAP2
	BRD8 EIF6 GNL2 GNL3 GTPBP4 KATNA1 KATNB1 MRTO4 PA2G4 RSL1D1 RSL24D1 SDAD1 TEX10 WDR18 ZNF593	O00488 O75449 O76021 P56537 Q13823 Q9BV38 Q9BVA0 Q9BVP2 Q9BZE4 Q9H0E9 Q9NVU7 Q9NXF1 Q9UHA3 Q9UKD2 Q9UQ80	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4428
	EEF1A1 EIF6 GNL2 GNL3 GTPBP4 KATNB1 MDN1 MRTO4 PA2G4 RSL1D1 RSL24D1 SDAD1 TEX10 WDR18 ZNF593	O00488 O76021 P56537 P68104 Q13823 Q9BV38 Q9BVA0 Q9BVP2 Q9BZE4 Q9NU22 Q9NVU7 Q9NXF1 Q9UHA3 Q9UKD2 Q9UQ80	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8826
	BMS1 BOP1 BRIX1 DDX18 FBL NOP2 NOP56 NOP58 PES1 RBM28 RPL3 SUMO1 SUMO2 UBC WDR12	O00541 O00567 P0CG48 P22087 P39023 P46087 P61956 P63165 Q14137 Q14692 Q8TDN6 Q9GZL7 Q9NVP1 Q9NW13 Q9Y2X3	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9560
	BOP1 DDX54 EBNA1BP2 NIP7 NOC2L NOP2 NVL PES1 RBM28 RPL5 RRP1B RSL1D1 SS18 WDR12 WDR74	O00541 O15381 O76021 P46087 P46777 Q14137 Q14684 Q15532 Q6RFH5 Q8TDD1 Q99848 Q9GZL7 Q9NW13 Q9Y221 Q9Y3T9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5644
	BOP1 H1-6 NVL PES1 RPL7L1 WDR12	O00541 O15381 P22492 Q14137 Q6DKI1 Q9GZL7	0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38071653

Sequence, Structure & Domains

Sequences

Length

606

Mass

66,194

Sequence

MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75083-1; Sequence=Displayed; Name=2; IsoId=O75083-3; Sequence=VSP_012926

Alternative Sequence

47..186; Missing (in isoform 2)

Domain & Motif Annotations

Repeat

4..45; WD 1; 48..87; WD 2; 93..135; WD 3; 138..176; WD 4; 180..218; WD 5; 224..263; WD 6; 270..306; WD 7; 311..351; WD 8; 358..408; WD 9; 432..474; WD 10; 480..518; WD 11; 523..561; WD 12; 566..604; WD 13

Protein Families

WD repeat AIP1 family

Sequence Similarities

Belongs to the WD repeat AIP1 family.

Clinical Relevance

Disease Involvement

Disease variant

Antibody (3)

CAB020804 HPA036434 HPA070293

Interaction Protein (2)

ENSG00000075624ENSG00000184009

Interaction Count

Interaction Dataset (2)

intact_biogrid_opencellbiogrid_opencell

Supporting Publications49

PMID	Title	Related sentences
35119778	Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis.	No related sentences available
35763629	Proteomic Profiling of Small Extracellular Vesicles Isolated from the Plasma of Vietnamese Patients with Non-Small Cell Lung Cancer Reveals Some Potential Biomarkers.	No related sentences available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No related sentences available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No related sentences available
36497184	Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.	No related sentences available
36736734	Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus.	No related sentences available
36982312	Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis.	No related sentences available
37204515	Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.	No related sentences available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No related sentences available
37438638	Extracellular Vesicles Play a Central Role in Cerebral Venous Disease-Associated Brain Atrophy.	No related sentences available

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