Protein detail

ICOSL

ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)

Protein symbol ICOSL	UniProt ID O75144	EVMP score 0.50
Frequency 5	Transmembrane count 1	Protein classification CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)

Protein Class

CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

CD markers
Predicted intracellular proteins

Transmembrane

257..277; Helical

Transmembrane Count

Ensembl

ENSG00000160223

Entrez Gene Symbol

ICOSLG

Gene Synonym

B7-H2B7hB7H2B7RP-1B7RP1CD275GL50ICOS-LICOSLKIAA0653

Gene Description

Inducible T cell costimulator ligand

Chromosome

Position

44215382-44241446

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificPlateletsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

CD markers
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M1315 Sig pip3 signaling in b lymphocytes
M8626 Sig bcr signaling pathway
M7955 Sig insulin receptor pathway in cardiac myocytes

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ICOSLG	PRKCA	P17252	S	285	phosphorylation	PhosphoSite

Ligand-Receptor Signaling

40 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ICOSL	O75144	ICOS	Q9Y6W8	Yes	Yes	No	iTALKKEGG-MEDICUSICELLNETSIGNORHINTCellPhoneDB_CellinkerUniProt_LRdbCellChatDBHPRDWojtowicz2020IntActWangCellPhoneDBBioGRIDBaccin2019CellinkerCellTalkDBNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	CellTalkDB:23954143 HPRD:10657606 IntAct:16951355 CellChatDB:23954143 HINT:11956294 SIGNOR:27559335 SPIKE_LC:10657606 NetPath:10657606 ICELLNET:14599850 BioGRID:11956294 Cellinker:23954143 Cellinker:25769613 Cellinker:29879883 HINT:16951355 connectomeDB2020:14599850 SPIKE:10657606 connectomeDB2020:23954143 ICELLNET:23954143 HINT:33033255 Cellinker:21955433 IntAct:11956294 HPRD:11023515 HPRD:11956294
KPCA	P17252	ICOSL	O75144	Yes	Yes	No	SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper	SIGNOR:24837102 PhosphoSite:24837102
KPCB	P05771	ICOSL	O75144	Yes	Yes	No	SIGNOR	SIGNOR:24837102

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ICOSLG	O75144	2	PDB	PDB:6x4t

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	2	38395386 38589887

Sequence, Structure & Domains

Sequences

Length

302

Mass

33,349

Sequence

MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTGHV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75144-1; Sequence=Displayed; Name=2; IsoId=O75144-2; Sequence=VSP_002520; Name=3; IsoId=O75144-3; Sequence=VSP_054718

Alternative Sequence

18..134; Missing (in isoform 3); 300..302; GHV -> ESWNLLLLLS (in isoform 2)

3D Structural Models

Turn

47..49; 78..83; 118..121; 174..177; 220..223

Helix

88..92; 105..107; 182..184; 193..195

Beta Strand

20..28; 33..35; 50..59; 62..66; 84..86; 98..102; 109..117; 122..136; 142..144; 155..165; 168..173; 185..191; 197..204; 213..219; 224..229

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

19..129; Ig-like V-type; 141..227; Ig-like C2-type

Protein Families

Immunoglobulin superfamily
BTN/MOG family

Sequence Similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Clinical Relevance

Drug Targets

Clinical trial target

Drugs

AMG-557 NULL

Antibody

CAB026037 HPA029179 CAB079997

Interaction Protein

ENSG00000163600

Interaction Count

Interaction Dataset

intact_biogrid