Protein detail

HIP1R

Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12)

Entry name HIP1R	UniProt ID O75146	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Cancer-related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12)

Protein Class (2)

Cancer-related genesPredicted intracellular proteins

Protein Function (2)

Cancer-related genes:Candidate cancer biomarkers
Predicted intracellular proteins

Ensembl

ENSG00000130787

Entrez Gene Symbol

HIP1R

Gene Synonym (5)

FLJ14000HIP12HIP3ILWEQKIAA0655

Gene Description

Huntingtin interacting protein 1 related

Chromosome

Position

122834453-122862961

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificBergmann gliaBlood Cell Specificclassical monocyte

Function & Pathway6

Protein Function (2)

Cancer-related genes:Candidate cancer biomarkers
Predicted intracellular proteins

Cellular Component (18)

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Molecular Function (14)

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Biological Process (3)

Reactome (5)

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence25

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (19)

19 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
HT_SC_Cluster237	HIP1 HIP1R SH3YL1 TLN1 TLN2 TLNRD1	O00291 O75146 Q96HL8 Q9H1K6 Q9Y490 Q9Y4G6	1:1:1:1:1:1	Compleat	Compleat:HC423
	AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP2B1 CLINT1 CLTA CLTB CLTC GAK GGA2 HIP1 HIP1R UBC	O00291 O14976 O43747 O75146 P09496 P09497 P0CG48 P61966 P63010 Q00610 Q10567 Q14677 Q9BXS5 Q9UJY4 Q9Y6Q5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5724
	GAK HIP1 HIP1R UBE2E1	O00291 O14976 O75146 P51965	0:0:0:0	hu.MAP2
	AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP2B1 CLINT1 CLTB CLTC HIP1 HIP1R PTGS2 SYNJ2 TOM1 UBC	O00291 O15056 O43747 O60784 O75146 P09497 P0CG48 P35354 P61966 P63010 Q00610 Q10567 Q14677 Q9BXS5 Q9Y6Q5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4093
	AP1B1 AP1G1 AP1M2 AP1S2 AP2B1 CLINT1 CLTA CLTB CLTC HIP1 HIP1R INPP5B SMURF1 TOM1 UBC	O00291 O43747 O60784 O75146 P09496 P09497 P0CG48 P32019 P56377 P63010 Q00610 Q10567 Q14677 Q9HCE7 Q9Y6Q5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5683
	HIP1 HIP1R	O00291 O75146	0:0	hu.MAP2
	CLTA CLTB CLTC DYNLL1 HIP1 HIP1R LDHA SEC14L4	O00291 O75146 P00338 P09496 P09497 P63167 Q00610 Q9UDX3	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6474
	ALDH2 CLTA CLTB CLTC GALE HIP1 HIP1R	O00291 O75146 P05091 P09496 P09497 Q00610 Q14376	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8876
	CLTA CLTB HIP1 HIP1R	O00291 O75146 P09496 P09497	1:1:1:1	CompleatCFinder	Compleat:HC6132
	CLTA CLTB CLTC CTRL DCUN1D5 HIP1 HIP1R HSPA8 LSM12 SEC14L4	O00291 O75146 P09496 P09497 P11142 P40313 Q00610 Q3MHD2 Q9BTE7 Q9UDX3	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9145

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27470641

Sequence, Structure & Domains15

Sequences

Length

1,068

Mass

119,388

Sequence

MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75146-1; Sequence=Displayed; Name=2; IsoId=O75146-2; Sequence=VSP_054238, VSP_054239

Alternative Sequence

606..615; ESQEQGLRQR -> VWPPQMQQHH (in isoform 2); 616..1068; Missing (in isoform 2)

3D Structural Models

Turn

929..931

Helix

776..778; 779..811; 814..852; 858..864; 866..895; 900..922; 932..964

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

425..443; Basic and acidic residues; 539..549; Basic and acidic residues; 590..600; Low complexity; 1049..1059; Basic and acidic residues

Coiled Coil

347..599

Domain (CC)

Binds F-actin via the talin-like I/LWEQ domain.

Domain (FT)

23..151; ENTH; 771..1012; I/LWEQ

Region

424..443; Disordered; 529..549; Disordered; 582..608; Disordered; 867..924; Important for actin binding; 1016..1060; Disordered

Protein Families

SLA2 family

Sequence Similarities

Belongs to the SLA2 family.

Clinical Relevance5

Disease Involvement

Cancer-related genes

Antibody (3)

CAB017187 HPA038135 HPA038136

Interaction Protein (2)

ENSG00000122705ENSG00000127946

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
30865381	Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114.	No abstract available