Protein detail

HIP1R

Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12)

Entry name HIP1R	UniProt ID O75146	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Cancer-related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12)

Protein Class (2)

Cancer-related genesPredicted intracellular proteins

Protein Function (2)

Cancer-related genes:Candidate cancer biomarkers
Predicted intracellular proteins

Ensembl

ENSG00000130787

Entrez Gene Symbol

HIP1R

Gene Synonym (5)

FLJ14000HIP12HIP3ILWEQKIAA0655

Gene Description

Huntingtin interacting protein 1 related

Chromosome

Position

122834453-122862961

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificBergmann gliaBlood Cell Specificclassical monocyte

Function & Pathway6

Protein Function (2)

Cancer-related genes:Candidate cancer biomarkers
Predicted intracellular proteins

Cellular Component (18)

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Molecular Function (14)

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Biological Process (3)

Reactome (5)

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence25

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (19)

19 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CLTA CLTB CLTC HIP1 HIP1R RAB37 RAB5A	O00291 O75146 P09496 P09497 P20339 Q00610 Q96AX2	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4226
CLTA CLTB CLTC DYNC1H1 GTF2E1 GTF2E2 HIP1 HIP1R	O00291 O75146 P09496 P09497 P29083 P29084 Q00610 Q14204	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9295
CDC5L CLTA CLTB CLTC DYNC1H1 GTF2E1 HDLBP HIP1 HIP1R PRPF8 SNW1	O00291 O75146 P09496 P09497 P29083 Q00341 Q00610 Q13573 Q14204 Q6P2Q9 Q99459	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4170
CLTA CLTB CLTC HIP1 HIP1R OSTM1 RPS10	O00291 O75146 P09496 P09497 P46783 Q00610 Q86WC4	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7541
CLTA CLTB CLTC FOXC1 HDLBP HIP1 HIP1R	O00291 O75146 P09496 P09497 Q00341 Q00610 Q12948	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8827
CPNE2 EBF3 HIP1 HIP1R USP24	O00291 O75146 Q96FN4 Q9H4W6 Q9UPU5	0:0:0:0:0	hu.MAP2
HIP1R	O75146	8	PDB	PDB:1r0d
AP2A1 DTNA HIP1R PICALM SEC24C SEC24D SH3GLB2	O75146 O94855 O95782 P53992 Q13492 Q9NR46 Q9Y4J8	0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_532
HIP1R PFKFB3	O75146 Q16875	0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27470641

Sequence, Structure & Domains15

Sequences

Length

1,068

Mass

119,388

Sequence

MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75146-1; Sequence=Displayed; Name=2; IsoId=O75146-2; Sequence=VSP_054238, VSP_054239

Alternative Sequence

606..615; ESQEQGLRQR -> VWPPQMQQHH (in isoform 2); 616..1068; Missing (in isoform 2)

3D Structural Models

Turn

929..931

Helix

776..778; 779..811; 814..852; 858..864; 866..895; 900..922; 932..964

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

425..443; Basic and acidic residues; 539..549; Basic and acidic residues; 590..600; Low complexity; 1049..1059; Basic and acidic residues

Coiled Coil

347..599

Domain (CC)

Binds F-actin via the talin-like I/LWEQ domain.

Domain (FT)

23..151; ENTH; 771..1012; I/LWEQ

Region

424..443; Disordered; 529..549; Disordered; 582..608; Disordered; 867..924; Important for actin binding; 1016..1060; Disordered

Protein Families

SLA2 family

Sequence Similarities

Belongs to the SLA2 family.

Clinical Relevance5

Disease Involvement

Cancer-related genes

Antibody (3)

CAB017187 HPA038135 HPA038136

Interaction Protein (2)

ENSG00000122705ENSG00000127946

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
30865381	Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114.	No abstract available