Protein detail
HIP1R
Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12)
Protein symbol HIP1R | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Cancer-related genesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12)
Protein Class
Cancer-related genesPredicted intracellular proteins
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ14000HIP12HIP3ILWEQKIAA0655
Gene Description
Huntingtin interacting protein 1 related
Chromosome
12
Position
122834453-122862961
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificBergmann gliaBlood Cell Specificclassical monocyte
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component
- GO:0005739 mitochondrion
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005905 clathrin-coated pit
- GO:0014069 postsynaptic density
- GO:0016324 apical plasma membrane
- GO:0030136 clathrin-coated vesicle
- GO:0030665 clathrin-coated vesicle membrane
- GO:0030864 cortical actin cytoskeleton
- GO:0032587 ruffle membrane
- GO:0032839 dendrite cytoplasm
- GO:0043025 neuronal cell body
- GO:0043197 dendritic spine
- GO:0043231 intracellular membrane-bounded organelle
- GO:0048471 perinuclear region of cytoplasm
- GO:0097060 synaptic membrane
- GO:0098843 postsynaptic endocytic zone
- GO:0098978 glutamatergic synapse
Molecular Function
- GO:0005515 protein binding
- GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
- GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
- GO:0017124 SH3 domain binding
- GO:0030276 clathrin binding
- GO:0032051 clathrin light chain binding
- GO:0035091 phosphatidylinositol binding
- GO:0035615 clathrin adaptor activity
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
- GO:0046982 protein heterodimerization activity
- GO:0051015 actin filament binding
- GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
19 records.
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27470641 |
Sequence, Structure & Domains
Sequences
Length
1,068
Mass
119,388
Sequence
MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75146-1; Sequence=Displayed; Name=2; IsoId=O75146-2; Sequence=VSP_054238, VSP_054239
Alternative Sequence
606..615; ESQEQGLRQR -> VWPPQMQQHH (in isoform 2); 616..1068; Missing (in isoform 2)
3D Structural Models
Turn
929..931
Helix
776..778; 779..811; 814..852; 858..864; 866..895; 900..922; 932..964
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
425..443; Basic and acidic residues; 539..549; Basic and acidic residues; 590..600; Low complexity; 1049..1059; Basic and acidic residues
Coiled Coil
347..599
Domain (CC)
Binds F-actin via the talin-like I/LWEQ domain.
Domain (FT)
23..151; ENTH; 771..1012; I/LWEQ
Region
424..443; Disordered; 529..549; Disordered; 582..608; Disordered; 867..924; Important for actin binding; 1016..1060; Disordered
Protein Families
SLA2 family
Sequence Similarities
Belongs to the SLA2 family.