Protein detail
GLRA3
Glycine receptor subunit alpha-3
Entry name GLRA3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Glycine receptor subunit alpha-3
Protein Function (2)
- Transporters:Transporter channels and pores
- FDA approved drug targets:Small molecule drugs
Transmembrane
256..277; Helical; Name=1; 283..303; Helical; Name=2; 315..335; Helical; Name=3; 431..451; Helical; Name=4
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Cell SpecificEndometrial ciliated cells
Function & Pathway8
Protein Function (2)
- Transporters:Transporter channels and pores
- FDA approved drug targets:Small molecule drugs
Cellular Component (9)
Molecular Function (9)
- GO:0004888 transmembrane signaling receptor activity
- GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity
- GO:0005254 chloride channel activity
- GO:0005515 protein binding
- GO:0016594 glycine binding
- GO:0016934 extracellularly glycine-gated chloride channel activity
- GO:0022852 glycine-gated chloride ion channel activity
- GO:0030594 neurotransmitter receptor activity
- GO:0046872 metal ion binding
Biological Process (3)
Reactome (3)
Canonical Pathways (3)
- M137 Pid vegf vegfr pathway
- M226 Pid vegfr1 pathway
- M33 Pid glypican 1pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence35
Ligand-Receptor Signaling (32)
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gaba_ach | receptor | Almen2009 | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| cys_loop | transporter | Surfaceome | No | Yes | No | No | No |
| channels | transporter | Surfaceome | No | Yes | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
Page 1 of 4Next
Protein Complex Composition (2)
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Glycine receptor complexGLRA3-GLRB | GLRA3GLRB | O75311P48167 | 4:1 | ComplexPortalPDB | PDB:9bozintact:EBI-44438063PDB:9boyPDB:9bp0PDB:9bp7 | 147552923601655735526563 |
| GLRA3 | O75311 | 5 | PDB | PDB:5vdhPDB:5tinPDB:5tioPDB:9bvhPDB:9bwePDB:9bzpPDB:9bvjPDB:9bwgPDB:9bu2PDB:9bwjPDB:9bwbPDB:5cfbPDB:9bwcPDB:5vdiPDB:9bu3 |
Sequence, Structure & Domains12
Sequences
Length
464
Mass
53,800
Sequence
MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Alpha-3L; IsoId=O75311-1; Sequence=Displayed; Name=Alpha-3K; IsoId=O75311-2; Sequence=VSP_000084
Alternative Sequence
358..372; Missing (in isoform Alpha-3K)
3D Structural Models
Turn
53..56; 86..89; 196..198; 304..306
Helix
43..50; 104..106; 120..125; 178..180; 254..259; 261..272; 273..276; 282..303; 315..341; 420..452; 454..456
Beta Strand
63..68; 70..85; 90..102; 110..112; 114..118; 131..133; 136..141; 144..146; 148..154; 157..170; 182..193; 199..203; 208..211; 218..222; 227..230; 232..235; 238..240; 242..250
3D Structure
Electron microscopy (14); X-ray crystallography (5)
Domain & Motif Annotations
Domain (CC)
The N-terminal domain carries structural determinants essential for agonist and antagonist binding. The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits (PubMed:26416729). The cytoplasmic loop is an important determinant of channel inactivation kinetics.
Protein Families (3)
- Ligand-gated ion channel (TC 1.A.9) family
- Glycine receptor (TC 1.A.9.3) subfamily
- GLRA3 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
Clinical Relevance1
Drugs
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 34265469 | Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer. | Furthermore, utilizing quantitative proteomics approach to reveal the proteomes of CD151-deleted exosomes and cells, we found that exosomal CD151 facilitated secretion of ribosomal proteins via exosomes while inhibiting exosome secretion of complement proteins. Moreover, we proved that CD151-deleted exosomes significantly decreased the migration and invasion of TNBC cells. Most importantly, we found that the tetraspanin CD151 expression levels in TNBC-derived serum exosomes were significantly higher than those exosomes from healthy subjects, and we validated our findings with samples from 16 additional donors. This is the first comparative study of the proteomes of TNBC patient-derived and CD151-deleted exosomes. |