Protein detail
GLRA3
Glycine receptor subunit alpha-3
Protein symbol GLRA3 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Glycine receptor subunit alpha-3
Protein Function
- Transporters:Transporter channels and pores
- FDA approved drug targets:Small molecule drugs
Transmembrane
256..277; Helical; Name=1; 283..303; Helical; Name=2; 315..335; Helical; Name=3; 431..451; Helical; Name=4
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEndometrial ciliated cells
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
- GO:0004888 transmembrane signaling receptor activity
- GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity
- GO:0005254 chloride channel activity
- GO:0005515 protein binding
- GO:0016594 glycine binding
- GO:0016934 extracellularly glycine-gated chloride channel activity
- GO:0022852 glycine-gated chloride ion channel activity
- GO:0030594 neurotransmitter receptor activity
- GO:0046872 metal ion binding
Biological Process
Reactome
Canonical Pathways
- M137 Pid vegf vegfr pathway
- M226 Pid vegfr1 pathway
- M33 Pid glypican 1pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ion_channel | ion_channel | Almen2009 | No | Yes | No | No | No |
| ligand_gated | ion_channel | Almen2009 | No | Yes | No | No | No |
| ligand_gated | ion_channel | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Glycine receptor complexGLRA3-GLRB | GLRA3GLRB | O75311P48167 | 4:1 | ComplexPortalPDB | PDB:9bozintact:EBI-44438063PDB:9boyPDB:9bp0PDB:9bp7 | 147552923601655735526563 |
| GLRA3 | O75311 | 5 | PDB | PDB:5vdhPDB:5tinPDB:5tioPDB:9bvhPDB:9bwePDB:9bzpPDB:9bvjPDB:9bwgPDB:9bu2PDB:9bwjPDB:9bwbPDB:5cfbPDB:9bwcPDB:5vdiPDB:9bu3 |
Sequence, Structure & Domains
Sequences
Length
464
Mass
53,800
Sequence
MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Alpha-3L; IsoId=O75311-1; Sequence=Displayed; Name=Alpha-3K; IsoId=O75311-2; Sequence=VSP_000084
Alternative Sequence
358..372; Missing (in isoform Alpha-3K)
3D Structural Models
Turn
53..56; 86..89; 196..198; 304..306
Helix
43..50; 104..106; 120..125; 178..180; 254..259; 261..272; 273..276; 282..303; 315..341; 420..452; 454..456
Beta Strand
63..68; 70..85; 90..102; 110..112; 114..118; 131..133; 136..141; 144..146; 148..154; 157..170; 182..193; 199..203; 208..211; 218..222; 227..230; 232..235; 238..240; 242..250
3D Structure
Electron microscopy (14); X-ray crystallography (5)
Domain & Motif Annotations
Domain (CC)
The N-terminal domain carries structural determinants essential for agonist and antagonist binding. The channel pore is formed by pentameric assembly of the second transmembrane domain from all five subunits (PubMed:26416729). The cytoplasmic loop is an important determinant of channel inactivation kinetics.
Protein Families
- Ligand-gated ion channel (TC 1.A.9) family
- Glycine receptor (TC 1.A.9.3) subfamily
- GLRA3 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
Clinical Relevance
Drugs