Protein detail

PITX3

Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3)

Entry name PITX3	UniProt ID O75364	EVMP confidence score 0.50
Supporting publications (n) 10	Transmembrane count	Protein classification Plasma proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3)

Protein Class (2)

Plasma proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins

Ensembl

ENSG00000163661

Entrez Gene Symbol

PTX3

Gene Synonym (2)

TNFAIP5TSG-14

Gene Description

Pentraxin 3

Chromosome

Position

157436850-157443633

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificretinaCell SpecificCone photoreceptor cellsSecretome LocationSecreted in other tissuesSecretome FunctionReceptor

Function & Pathway7

Protein Function

Predicted secreted proteins

Cellular Component (5)

Molecular Function (5)

Biological Process (3)

Reactome (2)

Canonical Pathways

M272 Pid cd8 tcr downstream pathway

Mediation Categories

Immune mediation

Relations & Evidence17

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	No	No
ecm	ecm	OmniPath	Yes	No	Yes	No	No
extracellular	extracellular	LOCATE	No	No	Yes	No	No
extracellular	extracellular	OmniPath	No	No	Yes	No	No
intracellular	intracellular	GO_Intercell	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
pentraxin	secreted_receptor	OmniPath	Yes	No	Yes	No	No
secreted_receptor	secreted_receptor	OmniPath	Yes	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTX3	P26022	CFAH	P08603	Yes	Yes	No	SIGNORHPRDHINTIntActInnateDBLit-BM-17	IntAct:22786770 IntAct:19050261 IntAct:28533443 SIGNOR:19050261 HINT:19050261 HPRD:19050261 Lit-BM-17:19632990 Lit-BM-17:19050261 InnateDB:19050261 HINT:19632990

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
PTX3	P26022	8	PDB	PDB:8s50PDB:7zl1
COLEC10 INHBE PTX3	P26022 P58166 Q9Y6Z7	0:0:0	hu.MAP
COLEC10 PTX3	P26022 Q9Y6Z7	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryFlow cytometryMORPH	1	37563857

Sequence, Structure & Domains8

Sequences

Length

302

Mass

31,832

Sequence

MEFGLLSEAEARSPALSLSDAGTPHPQLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGGPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDPCNSSLASLRLKAKQHASFSYPAVHGPPPAANLSPCQYAVERPV

Domain & Motif Annotations

Compositional Bias

31..43; Basic and acidic residues

Motif

262..275; OAR; 268..272; Nuclear localization signal

Region

1..71; Disordered

Protein Families (2)

Paired homeobox family
Bicoid subfamily

Sequence Similarities

Belongs to the paired homeobox family. Bicoid subfamily.

Clinical Relevance4

Antibody

HPA069320

Interaction Protein

ENSG00000138685

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications9

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
31196968	Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway.	No abstract available
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available
33035814	Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
34186243	A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.	No abstract available
38168906	Defining the relationship between cellular and extracellular vesicle (EV) content in breast cancer via an integrative multi-omic analysis.	No abstract available