Protein detail
PITX3
Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3)
Entry name PITX3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 10 | Transmembrane count | Protein classification Plasma proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3)
Protein Class (2)
Plasma proteinsPredicted secreted proteins
Protein Function
Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
TNFAIP5TSG-14
Gene Description
Pentraxin 3
Chromosome
3
Position
157436850-157443633
Supporting publications (n)
10
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue SpecificretinaCell SpecificCone photoreceptor cellsSecretome LocationSecreted in other tissuesSecretome FunctionReceptor
Function & Pathway7
Protein Function
Predicted secreted proteins
Cellular Component (5)
Molecular Function (5)
Biological Process (3)
Canonical Pathways
M272 Pid cd8 tcr downstream pathway
Mediation Categories
Immune mediation
Relations & Evidence17
Ligand-Receptor Signaling (12)
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
Page 2 of 2Previous
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTX3 | P26022 | CFAH | P08603 | Yes | Yes | No | SIGNORHPRDHINTIntActInnateDBLit-BM-17 | IntAct:22786770IntAct:19050261IntAct:28533443SIGNOR:19050261HINT:19050261HPRD:19050261Lit-BM-17:19632990Lit-BM-17:19050261InnateDB:19050261HINT:19632990 |
Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryFlow cytometryMORPH | 1 | 37563857 |
Sequence, Structure & Domains8
Sequences
Length
302
Mass
31,832
Sequence
MEFGLLSEAEARSPALSLSDAGTPHPQLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGGPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDPCNSSLASLRLKAKQHASFSYPAVHGPPPAANLSPCQYAVERPV
Domain & Motif Annotations
Compositional Bias
31..43; Basic and acidic residues
Motif
262..275; OAR; 268..272; Nuclear localization signal
Region
1..71; Disordered
Protein Families (2)
- Paired homeobox family
- Bicoid subfamily
Sequence Similarities
Belongs to the paired homeobox family. Bicoid subfamily.
Clinical Relevance4
Antibody
Interaction Protein
ENSG00000138685
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications9
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 31196968 | Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 33035814 | Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells. | No abstract available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 34186243 | A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis. | No abstract available |
| 38168906 | Defining the relationship between cellular and extracellular vesicle (EV) content in breast cancer via an integrative multi-omic analysis. | No abstract available |