Protein detail

PITX3

Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3)

Protein symbol PITX3	UniProt ID O75364	EVMP score 0.50
Frequency 10	Transmembrane count	Protein classification Plasma proteinsPredicted secreted proteins

Basic Information

Protein Names

Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3)

Protein Class

Plasma proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins

Ensembl

ENSG00000163661

Entrez Gene Symbol

PTX3

Gene Synonym

TNFAIP5TSG-14

Gene Description

Pentraxin 3

Chromosome

Position

157436850-157443633

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificretinaCell SpecificCone photoreceptor cellsSecretome LocationSecreted in other tissuesSecretome FunctionReceptor

Function & Pathway

Protein Function

Predicted secreted proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Canonical Pathways

M272 Pid cd8 tcr downstream pathway

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTX3	P26022	CFAH	P08603	Yes	Yes	No	SIGNORHPRDHINTIntActInnateDBLit-BM-17	IntAct:22786770 IntAct:19050261 IntAct:28533443 SIGNOR:19050261 HINT:19050261 HPRD:19050261 Lit-BM-17:19632990 Lit-BM-17:19050261 InnateDB:19050261 HINT:19632990

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
PTX3	P26022	8	PDB	PDB:8s50PDB:7zl1
COLEC10 INHBE PTX3	P26022 P58166 Q9Y6Z7	0:0:0	hu.MAP
COLEC10 PTX3	P26022 Q9Y6Z7	0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryFlow cytometryMORPH	1	37563857

Sequence, Structure & Domains

Sequences

Length

302

Mass

31,832

Sequence

MEFGLLSEAEARSPALSLSDAGTPHPQLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGGPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDPCNSSLASLRLKAKQHASFSYPAVHGPPPAANLSPCQYAVERPV

3D Structural Models

Domain & Motif Annotations

Compositional Bias

31..43; Basic and acidic residues

Motif

262..275; OAR; 268..272; Nuclear localization signal

Region

1..71; Disordered

Protein Families

Paired homeobox family
Bicoid subfamily

Sequence Similarities

Belongs to the paired homeobox family. Bicoid subfamily.

Clinical Relevance

Antibody

HPA069320

Interaction Protein

ENSG00000138685

Interaction Count

Interaction Dataset

intact_biogrid