Protein detail

TULP3

Tubby-related protein 3 (Tubby-like protein 3)

Protein symbol TULP3	UniProt ID O75386	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Tubby-related protein 3 (Tubby-like protein 3)

Protein Class

Disease related genesPredicted intracellular proteins

Protein Function

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000078246

Entrez Gene Symbol

TULP3

Gene Synonym

TUBL3

Gene Description

TUB like protein 3

Chromosome

Position

2877223-2941138

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainCell SpecificEarly spermatidsBlood Cell Specificneutrophil

Function & Pathway

Protein Function

Disease related genes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Receptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	No	No
ecm	ecm	OmniPath	Yes	No	Yes	No	No
extracellular	extracellular	OmniPath	No	No	Yes	No	No
intracellular	intracellular	LOCATE	No	No	Yes	No	No
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	GO_Intercell	No	No	Yes	No	No
intracellular	intracellular	UniProt_location	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	No	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TULP3	O75386	GP161	Q8N6U8	Yes	Yes	No	SIGNOR	SIGNOR:23332756

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	R Sequencing	1	31805958

Sequence, Structure & Domains

Sequences

Length

442

Mass

49,642

Sequence

MEASRCRLSPSGDSVFHEEMMKMRQAKLDYQRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVNCHTPHSNVILHGIDGPAAVLKPDEVHAPSVSSSVVEEDAENTVDTASKPGLQERLQKHDISESVNFDEETDGISQSACLERPNSASSQNSTDTGTSGSATAAQPADNLLGDIDDLEDFVYSPAPQGVTVRCRIIRDKRGMDRGLFPTYYMYLEKEENQKIFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLRSNLMGTKFTVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQPQNNHDSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIVHKNDPDYIVMQFGRVADDVFTLDYNYPLCAVQAFGIGLSSFDSKLACE

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75386-1; Sequence=Displayed; Name=2; IsoId=O75386-2; Sequence=VSP_054752; Name=3; IsoId=O75386-3; Sequence=VSP_055761, VSP_055762, VSP_055763

Alternative Sequence

1..19; Missing (in isoform 3); 165..189; DTGTSGSATAAQPADNLLGDIDDLE -> FSSFCQKTEDTGYRHFRFCYCRPTS (in isoform 3); 190..442; Missing (in isoform 3); 437..442; SKLACE -> KCIQTLRMQELCELHRQHHSAASLVHRTVCQRWVGHPWRLLPQTSLLWTDLSPPPVVPAPHQISM (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

145..162; Polar residues; 163..175; Low complexity

Region

23..68; Required for association with the IFT complex A (IFT-A); 101..177; Disordered

Protein Families

TUB family

Sequence Similarities

Belongs to the TUB family.

Clinical Relevance

Disease Involvement

CiliopathyDisease variant

Antibody

HPA015285 HPA018496

Interaction Protein

ENSG00000100124ENSG00000112182ENSG00000118965ENSG00000119650ENSG00000123607ENSG00000141568ENSG00000157796ENSG00000163913ENSG00000187535

Interaction Count

Interaction Dataset

intact_biogrid_opencellintact_biogridintact_biogrid_bioplex