Protein detail

MTU1

Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (MTO2 homolog)

Entry name
MTU1
UniProt ID
O75648
EVMP score
0.38
Frequency
2
Transmembrane count
Protein classification
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (MTO2 homolog)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Disease related genes
Ensembl
ENSG00000104907
Entrez Gene Symbol
TRMT1
Gene Synonym
FLJ20244TRM1
Gene Description
TRNA methyltransferase 1
Chromosome
19
Position
13104902-13117567
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificCardiomyocytes
Function & Pathway
Protein Function
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Other mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

51 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
FEN1TRMT1LVPS52VRK1P39748Q7Z2T5Q8N1B4Q999860:0:0:0Havugimana2012Havugimana2012:C_184
GALCTRMT11P54803Q7Z4G40:0hu.MAP2
NTPCRRPS20RPS27LRRP7ATRMT1LP60866Q71UM5Q7Z2T5Q9BSD7Q9Y3A40:0:0:0:0hu.MAP2
DHX33HNRNPUIGF2BP1SPATS2LTRMT1LQ00839Q7Z2T5Q9H6R0Q9NUQ6Q9NZI80:0:0:0:0hu.MAP
AMPD2TRMT1Q01433Q9NXH90:0hu.MAP
H1-10RRBP1TRMT1LUSP10Q14694Q7Z2T5Q92522Q9P2E90:0:0:0hu.MAP
TRMT12ZNF556Q53H54Q9HAH10:0hu.MAP2
TRMT10CQ7L0Y33PDBPDB:5nfj
NTPCRTRMT1LQ7Z2T5Q9BSD70:0hu.MAP2
DHX33TRMT1LUSP36Q7Z2T5Q9H6R0Q9P2750:0:0hu.MAP
Page 5 of 6PreviousNext

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry23539994938716512
Sequence, Structure & Domains

Sequences

Length
421
Mass
47,745
Sequence
MQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFSDFLNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNAVKLLQAADSFKDQTFFLSQVSQDALRRTIFPLGGLTKEFVKKIAAENRLHHVLQKKESMGMCFIGKRNFEHFLLQYLQPRPGHFISIEDNKVLGTHKGWFLYTLGQRANIGGLREPWYVVEKDSVKGDVFVAPRTDHPALYRDLLRTSRVHWIAEEPPAALVRDKMMECHFRFRHQMALVPCVLTLNQDGTVWVTAVQAVRALATGQFAVFYKGDECLGSGKILRLGPSAYTLQKGQRRAGMATESPSDSPEDGPGLSPLL
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=O75648-1; Sequence=Displayed; Name=2; IsoId=O75648-2; Sequence=VSP_035395; Name=3; IsoId=O75648-3; Sequence=VSP_035391, VSP_035392, VSP_035395; Name=4; IsoId=O75648-4; Sequence=VSP_035391, VSP_035392; Name=5; IsoId=O75648-5; Sequence=VSP_035393, VSP_035394
Alternative Sequence
1..154; Missing (in isoform 3 and isoform 4); 155..179; FEVRNAVKLLQAADSFKDQTFFLSQ -> MKKSLSRSTLRSPKGFSEIGLKLEM (in isoform 3 and isoform 4); 161..166; VKLLQA -> RFPRMP (in isoform 5); 167..421; Missing (in isoform 5); 341..421; PCVLTLNQDGTVWVTAVQAVRALATGQFAVFYKGDECLGSGKILRLGPSAYTLQKGQRRAGMATESPSDSPEDGPGLSPLL -> CCVLQGGRVPGQREDPAAGAVCLHAPEGPAQSWDGH (in isoform 2 and isoform 3)

3D Structural Models

Domain & Motif Annotations

Region
96..98; Interaction with target base in tRNA; 171..173; Interaction with tRNA; 334..335; Interaction with tRNA; 395..421; Disordered
Protein Families
MnmA/TRMU family
Sequence Similarities
Belongs to the MnmA/TRMU family.
Clinical Relevance
Disease Involvement
Disease variantIntellectual disability
Antibody
HPA041130HPA041380