Protein detail

MTU1

Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (MTO2 homolog)

Entry name MTU1	UniProt ID O75648	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) (MTO2 homolog)

Protein Class (7)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function (6)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Ensembl

ENSG00000104907

Entrez Gene Symbol

TRMT1

Gene Synonym (2)

FLJ20244TRM1

Gene Description

TRNA methyltransferase 1

Chromosome

Position

13104902-13117567

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Tissue Specificheart muscleCell SpecificCardiomyocytes

Function & Pathway6

Protein Function (6)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Cellular Component (3)

Molecular Function (5)

Biological Process (3)

Reactome (3)

Mediation Categories

Other mediation

Relations & Evidence57

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (51)

51 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
FEN1 TRMT1L VPS52 VRK1	P39748 Q7Z2T5 Q8N1B4 Q99986	0:0:0:0	Havugimana2012	Havugimana2012:C_184
GALC TRMT11	P54803 Q7Z4G4	0:0	hu.MAP2
NTPCR RPS20 RPS27L RRP7A TRMT1L	P60866 Q71UM5 Q7Z2T5 Q9BSD7 Q9Y3A4	0:0:0:0:0	hu.MAP2
DHX33 HNRNPU IGF2BP1 SPATS2L TRMT1L	Q00839 Q7Z2T5 Q9H6R0 Q9NUQ6 Q9NZI8	0:0:0:0:0	hu.MAP
AMPD2 TRMT1	Q01433 Q9NXH9	0:0	hu.MAP
H1-10 RRBP1 TRMT1L USP10	Q14694 Q7Z2T5 Q92522 Q9P2E9	0:0:0:0	hu.MAP
TRMT12 ZNF556	Q53H54 Q9HAH1	0:0	hu.MAP2
TRMT10C	Q7L0Y3	3	PDB	PDB:5nfj
NTPCR TRMT1L	Q7Z2T5 Q9BSD7	0:0	hu.MAP2
DHX33 TRMT1L USP36	Q7Z2T5 Q9H6R0 Q9P275	0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	35399949 38716512

Sequence, Structure & Domains8

Sequences

Length

421

Mass

47,745

Sequence

MQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFSDFLNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNAVKLLQAADSFKDQTFFLSQVSQDALRRTIFPLGGLTKEFVKKIAAENRLHHVLQKKESMGMCFIGKRNFEHFLLQYLQPRPGHFISIEDNKVLGTHKGWFLYTLGQRANIGGLREPWYVVEKDSVKGDVFVAPRTDHPALYRDLLRTSRVHWIAEEPPAALVRDKMMECHFRFRHQMALVPCVLTLNQDGTVWVTAVQAVRALATGQFAVFYKGDECLGSGKILRLGPSAYTLQKGQRRAGMATESPSDSPEDGPGLSPLL

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=O75648-1; Sequence=Displayed; Name=2; IsoId=O75648-2; Sequence=VSP_035395; Name=3; IsoId=O75648-3; Sequence=VSP_035391, VSP_035392, VSP_035395; Name=4; IsoId=O75648-4; Sequence=VSP_035391, VSP_035392; Name=5; IsoId=O75648-5; Sequence=VSP_035393, VSP_035394

Alternative Sequence

1..154; Missing (in isoform 3 and isoform 4); 155..179; FEVRNAVKLLQAADSFKDQTFFLSQ -> MKKSLSRSTLRSPKGFSEIGLKLEM (in isoform 3 and isoform 4); 161..166; VKLLQA -> RFPRMP (in isoform 5); 167..421; Missing (in isoform 5); 341..421; PCVLTLNQDGTVWVTAVQAVRALATGQFAVFYKGDECLGSGKILRLGPSAYTLQKGQRRAGMATESPSDSPEDGPGLSPLL -> CCVLQGGRVPGQREDPAAGAVCLHAPEGPAQSWDGH (in isoform 2 and isoform 3)

Domain & Motif Annotations

Region

96..98; Interaction with target base in tRNA; 171..173; Interaction with tRNA; 334..335; Interaction with tRNA; 395..421; Disordered

Protein Families

MnmA/TRMU family

Sequence Similarities

Belongs to the MnmA/TRMU family.

Clinical Relevance2

Disease Involvement (2)

Disease variantIntellectual disability

Antibody (2)

HPA041130 HPA041380

Supporting Publications2

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available