Protein detail

XRP2

Protein XRP2

Entry name XRP2	UniProt ID O75695	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein XRP2

Protein Class

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease

Ensembl

ENSG00000102218

Entrez Gene Symbol

RP2

Gene Synonym

NM23-H10NME10TBCCD2

Gene Description

RP2 activator of ARL3 GTPase

Chromosome

Position

46837043-46882358

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificadrenal glandCell SpecificAdrenal cortex cells

Function & Pathway

Protein Function

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

26 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
H3.3 com	ASF1A ASF1B ATRX CABIN1 DAXX H3-3A H4C4 HAT1 HIRA IPO4 NASP PARP1 PARP2 PRKDC RBBP4 RBBP7 TOP2A UBN1 XRCC5	O14929 P09874 P11388 P13010 P46100 P49321 P54198 P62805 P78527 P84243 Q09028 Q16576 Q8TEX9 Q9NPG3 Q9NVP2 Q9UER7 Q9UGN5 Q9Y294 Q9Y6J0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2014	14718166 20504901
HT_DM_Cluster258	GPAA1 MYPOP PNLIP PNLIPRP1 PNLIPRP2 PNLIPRP3	O43292 P16233 P54315 P54317 Q17RR3 Q86VE0	1:1:1:1:1:1	Compleat	Compleat:HC55	22036573
	A1CF ESRP2 RBM46 RBM47 RBMS1	A0AV96 P29558 Q8TBY0 Q9H6T0 Q9NQ94	0:0:0:0:0	hu.MAP2
	ESRP2 HNRNPLL LIMK2 SETD2 TBX3	O15119 P53671 Q8WVV9 Q9BYW2 Q9H6T0	0:0:0:0:0	hu.MAP2
	ESRP2 HNRNPLL TBX3	O15119 Q8WVV9 Q9H6T0	0:0:0	hu.MAP2
	H2AC21 MACROH2A1 PARP2 XPC XRCC5	O75367 P13010 Q01831 Q8IUE6 Q9UGN5	0:0:0:0:0	hu.MAP
	CETN2 MACROH2A1 PARP2 XPC	O75367 P41208 Q01831 Q9UGN5	0:0:0:0	hu.MAP
	OSTF1 RP2	O75695 Q92882	0:0	hu.MAP2
	H2AC4 H2BC11 H3C11 H4C4 PARP2	P04908 P06899 P62805 P68431 Q9UGN5	4:4:4:4:2	PDB	PDB:6usj
	ERO1A ERO1B ERP27 P4HB PDIA3 PDIA4 POMT2 UBC	P07237 P0CG48 P13667 P30101 Q86YB8 Q96DN0 Q96HE7 Q9UKY4	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9866

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	29148239 27894104

Sequence, Structure & Domains

Sequences

Length

350

Mass

39,641

Sequence

MGCFFSKRRKADKESRPENEEERPKQYSWDQREKVDPKDYMFSGLKDETVGRLPGTVAGQQFLIQDCENCNIYIFDHSATVTIDDCTNCIIFLGPVKGSVFFRNCRDCKCTLACQQFRVRDCRKLEVFLCCATQPIIESSSNIKFGCFQWYYPELAFQFKDAGLSIFNNTWSNIHDFTPVSGELNWSLLPEDAVVQDYVPIPTTEELKAVRVSTEANRSIVPISRGQRQKSSDESCLVVLFAGDYTIANARKLIDEMVGKGFFLVQTKEVSMKAEDAQRVFREKAPDFLPLLNKGPVIALEFNGDGAVEVCQLIVNEIFNGTKMFVSESKETASGDVDSFYNFADIQMGI

3D Structural Models

Turn

216..218

Helix

155..161; 195..197; 205..207; 246..259; 274..281; 282..287; 289..294; 307..318; 330..348

Beta Strand

39..44; 49..52; 62..66; 71..74; 81..85; 90..104; 106..121; 123..133; 136..139; 141..147; 175..178; 185..188; 235..240; 263..270; 297..304; 324..326

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

1..10; Basic residues; 11..31; Basic and acidic residues

Domain (FT)

24..179; C-CAP/cofactor C-like

Region

1..31; Disordered

Protein Families

TBCC family

Sequence Similarities

Belongs to the TBCC family.

Clinical Relevance

Disease Involvement

Disease variantRetinitis pigmentosa

Antibody

HPA000234 HPA000909

Interaction Protein

ENSG00000129353ENSG00000134996ENSG00000138175

Interaction Count

Interaction Dataset

biogrid_bioplexintact_biogrid