Protein detail

XRP2

Protein XRP2

Entry name
XRP2
UniProt ID
O75695
EVMP confidence score
0.40
Supporting publications (n)
1
Transmembrane count
Protein classification
Disease related genesHuman disease related genesPredicted intracellular proteins
Basic Information
Protein Names
Protein XRP2
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
  • Disease related genes
  • Predicted intracellular proteins
  • Human disease related genes:Nervous system diseases:Eye disease
Ensembl
ENSG00000102218
Entrez Gene Symbol
RP2
Gene Synonym (3)
NM23-H10NME10TBCCD2
Gene Description
RP2 activator of ARL3 GTPase
Chromosome
X
Position
46837043-46882358
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cells
Function & Pathway
Protein Function (3)
  • Disease related genes
  • Predicted intracellular proteins
  • Human disease related genes:Nervous system diseases:Eye disease
Cellular Component (11)
Page 1 of 2
Molecular Function (5)
Biological Process (3)
Reactome (4)
Mediation Categories
Other mediation
Relations & Evidence32

Ligand-Receptor Signaling (5)

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularOmniPath
plasma_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath

Protein Complex Composition (26)

26 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
APLFLIG3PARP2P49916Q8IW19Q9UGN50:0:0hu.MAP2
PNLIPRP2P543172PDBPDB:2oxePDB:2pvs
APLFHLTFPARP2Q14527Q8IW19Q9UGN50:0:0hu.MAP2
ERP27Q96DN05PDBPDB:4f9z
HPF1PARP2Q9NWY4Q9UGN51:2PDBPDB:6x0lPDB:6x0mPDB:6tx3
PARP2Q9UGN52PDBPDB:3kczPDB:9im8PDB:4pjvPDB:4tvjPDB:8jnyPDB:3kjdPDB:8hkoPDB:5dsyPDB:8hlqPDB:8hknPDB:8he8PDB:8hksPDB:4zzxPDB:6f5fPDB:6f5bPDB:8hlj
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry22914823927894104
Sequence, Structure & Domains

Sequences

Length
350
Mass
39,641
Sequence
MGCFFSKRRKADKESRPENEEERPKQYSWDQREKVDPKDYMFSGLKDETVGRLPGTVAGQQFLIQDCENCNIYIFDHSATVTIDDCTNCIIFLGPVKGSVFFRNCRDCKCTLACQQFRVRDCRKLEVFLCCATQPIIESSSNIKFGCFQWYYPELAFQFKDAGLSIFNNTWSNIHDFTPVSGELNWSLLPEDAVVQDYVPIPTTEELKAVRVSTEANRSIVPISRGQRQKSSDESCLVVLFAGDYTIANARKLIDEMVGKGFFLVQTKEVSMKAEDAQRVFREKAPDFLPLLNKGPVIALEFNGDGAVEVCQLIVNEIFNGTKMFVSESKETASGDVDSFYNFADIQMGI

3D Structural Models

Turn
216..218
Helix
155..161; 195..197; 205..207; 246..259; 274..281; 282..287; 289..294; 307..318; 330..348
Beta Strand
39..44; 49..52; 62..66; 71..74; 81..85; 90..104; 106..121; 123..133; 136..139; 141..147; 175..178; 185..188; 235..240; 263..270; 297..304; 324..326
3D Structure
X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias
1..10; Basic residues; 11..31; Basic and acidic residues
Domain (FT)
24..179; C-CAP/cofactor C-like
Region
1..31; Disordered
Protein Families
TBCC family
Sequence Similarities
Belongs to the TBCC family.
Clinical Relevance
Disease Involvement (2)
Disease variantRetinitis pigmentosa
Related Diseases
Retinitis pigmentosa
Antibody (2)
HPA000234HPA000909
Interaction Protein (3)
ENSG00000129353ENSG00000134996ENSG00000138175
Interaction Count
3
Interaction Dataset (2)
biogrid_bioplexintact_biogrid
Supporting Publications1
PMIDTitleRelated sentences
32384937Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.No related sentences available