Protein detail
XRP2
Protein XRP2
Entry name XRP2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein XRP2
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Eye disease
Ensembl
Entrez Gene Symbol
Gene Synonym
NM23-H10NME10TBCCD2
Gene Description
RP2 activator of ARL3 GTPase
Chromosome
X
Position
46837043-46882358
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
26 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| APLFLIG3PARP2 | P49916Q8IW19Q9UGN5 | 0:0:0 | hu.MAP2 | |||
| PNLIPRP2 | P54317 | 2 | PDB | PDB:2oxePDB:2pvs | ||
| APLFHLTFPARP2 | Q14527Q8IW19Q9UGN5 | 0:0:0 | hu.MAP2 | |||
| ERP27 | Q96DN0 | 5 | PDB | PDB:4f9z | ||
| HPF1PARP2 | Q9NWY4Q9UGN5 | 1:2 | PDB | PDB:6x0lPDB:6x0mPDB:6tx3 | ||
| PARP2 | Q9UGN5 | 2 | PDB | PDB:3kczPDB:9im8PDB:4pjvPDB:4tvjPDB:8jnyPDB:3kjdPDB:8hkoPDB:5dsyPDB:8hlqPDB:8hknPDB:8he8PDB:8hksPDB:4zzxPDB:6f5fPDB:6f5bPDB:8hlj |
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Sequence, Structure & Domains
Sequences
Length
350
Mass
39,641
Sequence
MGCFFSKRRKADKESRPENEEERPKQYSWDQREKVDPKDYMFSGLKDETVGRLPGTVAGQQFLIQDCENCNIYIFDHSATVTIDDCTNCIIFLGPVKGSVFFRNCRDCKCTLACQQFRVRDCRKLEVFLCCATQPIIESSSNIKFGCFQWYYPELAFQFKDAGLSIFNNTWSNIHDFTPVSGELNWSLLPEDAVVQDYVPIPTTEELKAVRVSTEANRSIVPISRGQRQKSSDESCLVVLFAGDYTIANARKLIDEMVGKGFFLVQTKEVSMKAEDAQRVFREKAPDFLPLLNKGPVIALEFNGDGAVEVCQLIVNEIFNGTKMFVSESKETASGDVDSFYNFADIQMGI
3D Structural Models
Turn
216..218
Helix
155..161; 195..197; 205..207; 246..259; 274..281; 282..287; 289..294; 307..318; 330..348
Beta Strand
39..44; 49..52; 62..66; 71..74; 81..85; 90..104; 106..121; 123..133; 136..139; 141..147; 175..178; 185..188; 235..240; 263..270; 297..304; 324..326
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
1..10; Basic residues; 11..31; Basic and acidic residues
Domain (FT)
24..179; C-CAP/cofactor C-like
Region
1..31; Disordered
Protein Families
TBCC family
Sequence Similarities
Belongs to the TBCC family.