Protein detail
CBPD
Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)
Entry name CBPD | UniProt ID | EVMP confidence score 0.47 |
Supporting publications (n) 16 | Transmembrane count 1 | Protein classification EnzymesPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)
Protein Class (3)
EnzymesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (4)
- Peptidases:Metallopeptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Transmembrane
1300..1320; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
GP180
Gene Description
Carboxypeptidase D
Chromosome
17
Position
30378927-30469989
Supporting publications (n)
16
EVMP confidence score
0.47
Fluorescence & Localization3
Tissue SpecificbrainCell SpecificCone photoreceptor cellsBlood Cell Specificbasophil
Function & Pathway6
Protein Function (4)
- Peptidases:Metallopeptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (4)
Molecular Function (3)
Biological Process
Reactome (8)
- R-hsa-432722 golgi associated vesicle biogenesis
- R-hsa-199991 membrane trafficking
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9696273 rnd1 gtpase cycle
- R-hsa-9696264 rnd3 gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-199992 trans golgi network vesicle budding
- R-hsa-5653656 vesicle mediated transport
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence36
Ligand-Receptor Signaling (29)
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | Surfaceome | Yes | No | No | Yes | No |
| m14_carboxypeptidase | cell_surface_peptidase | OmniPath | Yes | No | No | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | No | No | Yes | No |
| cell_surface_peptidase | cell_surface_peptidase | OmniPath | Yes | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
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Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CPD | O75976 | 2 | PDB | PDB:5aq0 | ||
| GPCPD1SLC35D3 | Q5M8T2Q9NPB8 | 0:0 | hu.MAP2 | |||
| SCCPDHUSP13 | Q8NBX0Q92995 | 0:0 | hu.MAP | |||
| CRIPTSCCPDHTMEM160USP13 | Q8NBX0Q92995Q9NX00Q9P021 | 0:0:0:0 | hu.MAP2 | |||
| CRIPTSCCPDHUSP13 | Q8NBX0Q92995Q9P021 | 0:0:0 | hu.MAP2 | |||
| GPCPD1 | Q9NPB8 | 6 | PDB | PDB:2z0b |
Sequence, Structure & Domains15
Sequences
Length
1,380
Mass
152,931
Sequence
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75976-1; Sequence=Displayed; Name=2; IsoId=O75976-2; Sequence=VSP_045833, VSP_045834
Alternative Sequence
1..2; MA -> MR (in isoform 2); 3..249; Missing (in isoform 2)
3D Structural Models
Turn
391..393
Beta Strand
383..390; 401..404; 417..422; 425..433; 440..447; 449..451; 457..459
3D Structure
Electron microscopy (2); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
195..204; Gly residues; 887..897; Polar residues
Motif
162..164; Cell attachment site
Domain (CC)
There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.
Domain (FT)
57..380; Peptidase M14 1; 502..792; Peptidase M14 2; 932..1211; Peptidase M14 3
Region
190..232; Disordered; 874..899; Disordered; 1359..1380; Disordered
Protein Families
Peptidase M14 family
Sequence Similarities
Belongs to the peptidase M14 family.
Clinical Relevance5
Drugs (11)
Antibody
Interaction Protein
ENSG00000127022
Interaction Count
1
Interaction Dataset
biogrid_opencell
Supporting Publications16
| PMID | Title | Abstract |
|---|---|---|
| 26378940 | Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis. | No abstract available |
| 27863537 | High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. | No abstract available |
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28590090 | Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 29148239 | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | No abstract available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 30950185 | Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 33035814 | Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells. | No abstract available |
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