Protein detail
CBPD
Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)
Entry name CBPD | UniProt ID | EVMP score 0.47 |
Frequency 16 | Transmembrane count 1 | Protein classification EnzymesPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)
Protein Class
EnzymesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Transmembrane
1300..1320; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
GP180
Gene Description
Carboxypeptidase D
Chromosome
17
Position
30378927-30469989
Frequency
16
EVMP Score
0.47
Fluorescence & Localization
Tissue SpecificbrainCell SpecificCone photoreceptor cellsBlood Cell Specificbasophil
Function & Pathway
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-432722 golgi associated vesicle biogenesis
- R-hsa-199991 membrane trafficking
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9696273 rnd1 gtpase cycle
- R-hsa-9696264 rnd3 gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-199992 trans golgi network vesicle budding
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CPD | O75976 | 2 | PDB | PDB:5aq0 | ||
| GPCPD1SLC35D3 | Q5M8T2Q9NPB8 | 0:0 | hu.MAP2 | |||
| SCCPDHUSP13 | Q8NBX0Q92995 | 0:0 | hu.MAP | |||
| CRIPTSCCPDHTMEM160USP13 | Q8NBX0Q92995Q9NX00Q9P021 | 0:0:0:0 | hu.MAP2 | |||
| CRIPTSCCPDHUSP13 | Q8NBX0Q92995Q9P021 | 0:0:0 | hu.MAP2 | |||
| GPCPD1 | Q9NPB8 | 6 | PDB | PDB:2z0b |
Sequence, Structure & Domains
Sequences
Length
1,380
Mass
152,931
Sequence
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75976-1; Sequence=Displayed; Name=2; IsoId=O75976-2; Sequence=VSP_045833, VSP_045834
Alternative Sequence
1..2; MA -> MR (in isoform 2); 3..249; Missing (in isoform 2)
3D Structural Models
Turn
391..393
Beta Strand
383..390; 401..404; 417..422; 425..433; 440..447; 449..451; 457..459
3D Structure
Electron microscopy (2); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
195..204; Gly residues; 887..897; Polar residues
Motif
162..164; Cell attachment site
Domain (CC)
There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.
Domain (FT)
57..380; Peptidase M14 1; 502..792; Peptidase M14 2; 932..1211; Peptidase M14 3
Region
190..232; Disordered; 874..899; Disordered; 1359..1380; Disordered
Protein Families
Peptidase M14 family
Sequence Similarities
Belongs to the peptidase M14 family.
Clinical Relevance
Drugs
Antibody
Interaction Protein
ENSG00000127022
Interaction Count
1
Interaction Dataset
biogrid_opencell