Protein detail

CBPD

Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)

Entry name CBPD	UniProt ID O75976	EVMP confidence score 0.47
Supporting publications (n) 16	Transmembrane count 1	Protein classification EnzymesPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180)

Protein Class (3)

EnzymesPredicted intracellular proteinsPredicted membrane proteins

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Transmembrane

1300..1320; Helical

Transmembrane Count

Ensembl

ENSG00000108582

Entrez Gene Symbol

CPD

Gene Synonym

GP180

Gene Description

Carboxypeptidase D

Chromosome

Position

30378927-30469989

Supporting publications (n)

EVMP confidence score

0.47

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificCone photoreceptor cellsBlood Cell Specificbasophil

Function & Pathway6

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Cellular Component (4)

Molecular Function (3)

Biological Process

GO:0008150 biological_process

Reactome (8)

Mediation Categories (3)

Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence36

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No

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Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CPD	O75976	2	PDB	PDB:5aq0
GPCPD1 SLC35D3	Q5M8T2 Q9NPB8	0:0	hu.MAP2
SCCPDH USP13	Q8NBX0 Q92995	0:0	hu.MAP
CRIPT SCCPDH TMEM160 USP13	Q8NBX0 Q92995 Q9NX00 Q9P021	0:0:0:0	hu.MAP2
CRIPT SCCPDH USP13	Q8NBX0 Q92995 Q9P021	0:0:0	hu.MAP2
GPCPD1	Q9NPB8	6	PDB	PDB:2z0b

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	2	38113368 38207106

Sequence, Structure & Domains15

Sequences

Length

1,380

Mass

152,931

Sequence

MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75976-1; Sequence=Displayed; Name=2; IsoId=O75976-2; Sequence=VSP_045833, VSP_045834

Alternative Sequence

1..2; MA -> MR (in isoform 2); 3..249; Missing (in isoform 2)

3D Structural Models

Turn

391..393

Beta Strand

383..390; 401..404; 417..422; 425..433; 440..447; 449..451; 457..459

3D Structure

Electron microscopy (2); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

195..204; Gly residues; 887..897; Polar residues

Motif

162..164; Cell attachment site

Domain (CC)

There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.

Domain (FT)

57..380; Peptidase M14 1; 502..792; Peptidase M14 2; 932..1211; Peptidase M14 3

Region

190..232; Disordered; 874..899; Disordered; 1359..1380; Disordered

Protein Families

Peptidase M14 family

Sequence Similarities

Belongs to the peptidase M14 family.

Clinical Relevance5

Drugs (11)

FADROZOLE ENDOXIFEN AMINOGLUTETHIMIDE LETROZOLE TESTOLACTONE EXEMESTANE ANTISERUM ANASTROZOLE (2S,4S)-KETOCONAZOLE AZALANSTAT NORENDOXIFEN

Antibody

HPA052796

Interaction Protein

ENSG00000127022

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications16

PMID	Title	Abstract
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No abstract available
38168906	Defining the relationship between cellular and extracellular vesicle (EV) content in breast cancer via an integrative multi-omic analysis.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
39409015	SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy.	No abstract available
40089067	Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells.	No abstract available

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