Protein detail
VAMP5
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Entry name VAMP5 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Protein Class
Predicted membrane proteins
Transmembrane
73..93; Helical; Anchor for type IV membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Vesicle associated membrane protein 5
Chromosome
2
Position
85584431-85593406
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization2
Cell SpecificLate spermatids
Function & Pathway5
Cellular Component (9)
Molecular Function
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence20
Ligand-Receptor Signaling (19)
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32002171 |
Sequence, Structure & Domains7
Sequences
Length
116
Mass
12,805
Sequence
MAGIELERCQQQANEVTEIMRNNFGKVLERGVKLAELQQRSDQLLDMSSTFNKTTQNLAQKKCWENIRYRICVGLVVVGVLLIILIVLLVVFLPQSSDSSSAPRTQDAGIASGPGN
Domain & Motif Annotations
Domain (FT)
5..65; v-SNARE coiled-coil homology
Region
96..116; Disordered
Protein Families
Synaptobrevin family
Sequence Similarities
Belongs to the synaptobrevin family.
Clinical Relevance4
Antibody
Interaction Protein (23)
ENSG00000053501ENSG00000086827ENSG00000092108ENSG00000099940ENSG00000103496ENSG00000104915ENSG00000105402ENSG00000106089ENSG00000108587ENSG00000108679ENSG00000117758ENSG00000124207ENSG00000124222ENSG00000125991ENSG00000134265ENSG00000135249ENSG00000135823ENSG00000136631ENSG00000136874ENSG00000162236ENSG00000164294ENSG00000170310ENSG00000177951
Interaction Count
23
Interaction Dataset (3)
biogrid_bioplexintact_biogrid_bioplexintact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 20080967 | Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligands. | Whereas ULBP2 is mainly shed by metalloproteases, ULBP3 is abundantly released as part of membrane vesicles known as exosomes. |