Protein detail
CSPG5
Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C)
Entry name CSPG5 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 7 | Transmembrane count 1 | Protein classification Predicted membrane proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C)
Protein Class (2)
Predicted membrane proteinsPredicted secreted proteins
Protein Function
Predicted secreted proteins
Transmembrane
424..444; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
NGC
Gene Description
Chondroitin sulfate proteoglycan 5
Chromosome
3
Position
47562238-47580792
Supporting publications (n)
7
EVMP confidence score
0.63
Fluorescence & Localization4
Tissue SpecificintestineCell SpecificSchwann cellsSingle-Nuclei Brain Specificfibroblast
Function & Pathway6
Protein Function
Predicted secreted proteins
Cellular Component (14)
- GO:0000139 Golgi membrane
- GO:0005576 extracellular region
- GO:0005789 endoplasmic reticulum membrane
- GO:0005794 Golgi apparatus
- GO:0005796 Golgi lumen
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0030660 Golgi-associated vesicle membrane
- GO:0043202 lysosomal lumen
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Molecular Function (2)
Biological Process (3)
Reactome (14)
- R-hsa-1793185 chondroitin sulfate dermatan sulfate metabolism
- R-hsa-2024101 cs ds degradation
- R-hsa-2022870 cs gag biosynthesis
- R-hsa-3560783 defective b4galt7 causes eds progeroid type
- R-hsa-3595174 defective chst14 causes eds musculocontractural type
- R-hsa-3595172 defective chst3 causes sedcjd
- R-hsa-3595177 defective chsy1 causes tpbs
- R-hsa-3560782 diseases associated with glycosaminoglycan metabolism
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
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Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence34
Ligand-Receptor Signaling (30)
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_location | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32002171 |
Sequence, Structure & Domains8
Sequences
Length
566
Mass
60,016
Sequence
MGRAGGGGPGRGPPPLLLFLGAALVLASGAVPAREAGSAVEAEELVKGSPAWEPPANDTREEAGPPAAGEDEASWTAPGGELAGPEEVLQESAAVTGTAWLEADSPGLGGVTAEAGSGDAQALPATLQAPHEVLGQSIMPPAIPEATEASGPPSPTPGDKLSPASELPKESPLEVWLNLGGSTPDPQGPELTYPFQGTLEPQPASDIIDIDYFEGLDGEGRGADLGSFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLDEEEEEEEDDKDAVGGGDLEDENELLVPTGKPGLGPGTGQPTSRWHAVPPQHTLGSVPGSSIALRPRPGEPGRDLASSENGTECRSGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAKKLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNVRKLCNTPRTSSPHARALAHYDNVICQDDPSAPHKIQEVLKSCLKEEESFNIQNSMSPKLEGGKGDQADLDVNCLQNNLT
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O95196-1; Sequence=Displayed; Name=2; Synonyms=CSPG5-I; IsoId=O95196-2; Sequence=VSP_015761; Name=3; Synonyms=CSPG5-II; IsoId=O95196-3; Sequence=VSP_015760, VSP_015761
Alternative Sequence
1..138; Missing (in isoform 3); 487..513; Missing (in isoform 2 and isoform 3)
Domain & Motif Annotations
Compositional Bias
273..286; Acidic residues
Domain (FT)
371..413; EGF-like
Region
39..82; Disordered; 143..202; Disordered; 215..248; Disordered; 262..354; Disordered; 264..301; Interaction with TNC and TNR; 442..460; Interaction with GOPC
Supporting Publications7
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 29148239 | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 37205098 | Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers. | No abstract available |
| 39940641 | Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients. | No abstract available |
| 40089067 | Metabolic Reprogramming Into a Glycolysis Phenotype Induced by Extracellular Vesicles Derived From Prostate Cancer Cells. | No abstract available |
| 40748658 | Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures. | No abstract available |