Protein detail
CSPG5
Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C)
Protein symbol CSPG5 | UniProt ID | EVMP score 0.63 |
Frequency 7 | Transmembrane count 1 | Protein classification Predicted membrane proteinsPredicted secreted proteins |
Basic Information
Protein Names
Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C)
Protein Class
Predicted membrane proteinsPredicted secreted proteins
Protein Function
Predicted secreted proteins
Transmembrane
424..444; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
NGC
Gene Description
Chondroitin sulfate proteoglycan 5
Chromosome
3
Position
47562238-47580792
Frequency
7
EVMP Score
0.63
Fluorescence & Localization
Tissue SpecificintestineCell SpecificSchwann cellsSingle-Nuclei Brain Specificfibroblast
Function & Pathway
Protein Function
Predicted secreted proteins
Cellular Component
- GO:0000139 Golgi membrane
- GO:0005576 extracellular region
- GO:0005789 endoplasmic reticulum membrane
- GO:0005794 Golgi apparatus
- GO:0005796 Golgi lumen
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0030660 Golgi-associated vesicle membrane
- GO:0043202 lysosomal lumen
- GO:0045202 synapse
- GO:0045211 postsynaptic membrane
- GO:0098978 glutamatergic synapse
- GO:0098982 GABA-ergic synapse
Molecular Function
Biological Process
Reactome
- R-hsa-1793185 chondroitin sulfate dermatan sulfate metabolism
- R-hsa-2024101 cs ds degradation
- R-hsa-2022870 cs gag biosynthesis
- R-hsa-3560783 defective b4galt7 causes eds progeroid type
- R-hsa-3595174 defective chst14 causes eds musculocontractural type
- R-hsa-3595172 defective chst3 causes sedcjd
- R-hsa-3595177 defective chsy1 causes tpbs
- R-hsa-3560782 diseases associated with glycosaminoglycan metabolism
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-2022923 ds gag biosynthesis
- R-hsa-1630316 glycosaminoglycan metabolism
- R-hsa-1971475 glycosaminoglycan protein linkage region biosynthesis
- R-hsa-71387 metabolism of carbohydrates and carbohydrate derivatives
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| ligand | ligand | GO_Intercell | Yes | No | Yes | Yes | No |
| growth_factor | ligand | DGIdb | Yes | No | Yes | Yes | No |
| ligand | ligand | DGIdb | Yes | No | Yes | Yes | No |
| ligand | ligand | OmniPath | Yes | No | Yes | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32002171 |
Sequence, Structure & Domains
Sequences
Length
566
Mass
60,016
Sequence
MGRAGGGGPGRGPPPLLLFLGAALVLASGAVPAREAGSAVEAEELVKGSPAWEPPANDTREEAGPPAAGEDEASWTAPGGELAGPEEVLQESAAVTGTAWLEADSPGLGGVTAEAGSGDAQALPATLQAPHEVLGQSIMPPAIPEATEASGPPSPTPGDKLSPASELPKESPLEVWLNLGGSTPDPQGPELTYPFQGTLEPQPASDIIDIDYFEGLDGEGRGADLGSFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLDEEEEEEEDDKDAVGGGDLEDENELLVPTGKPGLGPGTGQPTSRWHAVPPQHTLGSVPGSSIALRPRPGEPGRDLASSENGTECRSGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAKKLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNVRKLCNTPRTSSPHARALAHYDNVICQDDPSAPHKIQEVLKSCLKEEESFNIQNSMSPKLEGGKGDQADLDVNCLQNNLT
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O95196-1; Sequence=Displayed; Name=2; Synonyms=CSPG5-I; IsoId=O95196-2; Sequence=VSP_015761; Name=3; Synonyms=CSPG5-II; IsoId=O95196-3; Sequence=VSP_015760, VSP_015761
Alternative Sequence
1..138; Missing (in isoform 3); 487..513; Missing (in isoform 2 and isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
273..286; Acidic residues
Domain (FT)
371..413; EGF-like
Region
39..82; Disordered; 143..202; Disordered; 215..248; Disordered; 262..354; Disordered; 264..301; Interaction with TNC and TNR; 442..460; Interaction with GOPC