Protein detail
MRP6
ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6)
Entry name MRP6 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 7 | Transmembrane count 17 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6)
Protein Function (8)
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Transporters:Primary Active Transporters
- Disease related genes
Transmembrane
32..52; Helical; Name=1; 73..93; Helical; Name=2; 99..119; Helical; Name=3; 132..149; Helical; Name=4; 168..188; Helical; Name=5; 303..323; Helical; Name=6; 350..370; Helical; Name=7; 427..447; Helical; Name=8; 451..471; Helical; Name=9; 534..554; Helical; Name=10; 576..596; Helical; Name=11; 940..960; Helical; Name=12; 998..1018; Helical; Name=13; 1062..1082; Helical; Name=14; 1084..1104; Helical; Name=15; 1176..1196; Helical; Name=16; 1199..1219; Helical; Name=17
Transmembrane Count
17
Ensembl
Entrez Gene Symbol
Supporting publications (n)
7
EVMP confidence score
0.63
Fluorescence & Localization3
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway7
Protein Function (8)
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Transporters:Primary Active Transporters
- Disease related genes
Cellular Component (7)
Molecular Function (5)
Biological Process (3)
Reactome (4)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence28
Ligand-Receptor Signaling (26)
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| abcc | transporter | Almen2009 | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 38321535 |
Sequence, Structure & Domains14
Sequences
Length
1,503
Mass
164,906
Sequence
MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O95255-1; Sequence=Displayed; Name=2; Synonyms=URG7; IsoId=O95255-2; Sequence=VSP_047315, VSP_047316; Name=3; Synonyms=Delta19Delta24; IsoId=O95255-3; Sequence=VSP_057077, VSP_057078
Alternative Sequence
75..99; LGFALIVLCTSSVAVALWKIQQGTP -> AAIPGSLEPGNVRGRQGTGWNLVKS (in isoform 2); 100..1503; Missing (in isoform 2); 806..871; TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTST -> KQNLGPAPRTPEAPLQAGGPSLDARGPSSQSLRRTVPLQKPRQRFLWMTLTGQDGQQERTASNTAG (in isoform 3); 872..1503; Missing (in isoform 3)
3D Structural Models
Turn
801..804; 1445..1450
Helix
669..676; 707..712; 719..728; 732..737; 741..743; 755..768; 785..795; 817..819; 837..842; 846..852; 1305..1312; 1330..1332; 1335..1340; 1356..1360; 1368..1377; 1381..1386; 1390..1392; 1404..1417; 1434..1444; 1460..1463; 1483..1488; 1492..1499
Beta Strand
627..639; 645..654; 658..662; 680..689; 693..696; 704..706; 738..740; 745..751; 772..778; 781..783; 805..810; 820..827; 830..835; 1265..1272; 1274..1278; 1281..1289; 1294..1298; 1319..1325; 1342..1345; 1353..1355; 1387..1389; 1421..1426; 1430..1432; 1451..1459; 1464..1473; 1476..1481
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
881..901; Basic and acidic residues
Domain (FT)
311..593; ABC transmembrane type-1 1; 629..853; ABC transporter 1; 947..1228; ABC transmembrane type-1 2; 1265..1499; ABC transporter 2
Region
854..919; Disordered
Protein Families (3)
- ABC transporter superfamily
- ABCC family
- Conjugate transporter (TC 3.A.1.208) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Clinical Relevance1
Drugs (60)
TOLVAPTAN[PHAA1,D-TYR(ET)2,VAL4,LYS6,TYR-NH28,DES-GLY9]AVPD(CH2)5[TYR(ME)2,THR4,TYR-NH29]OVTD[VAL4,DARG8]VP[3H]DDAVPDESMOPRESSINOH-LVAARGIPRESSINSKF-105494[PHAA1,D-TYR2,VAL4,ARG6,ARG-NH29]AVPYM 471LVPD(CH2)5[D-ILE2,VAL4,TYR-NH29]AVPMOZAVAPTAND(CH2)5[TYR(ME)2]AVPD(CH2)5[D-ILE2,ILE4,ALA-NH29]AVPCONIVAPTANRO5028442OPC-51803D[D-PAL2]AVPARGIPRESTOCIN[3H]AVP (HUMAN, MOUSE, RAT)D[D-PHE2]AVPD(CH2)5[D-TYR(ET)2,VAL4,TYR-NH29]AVP[3H]DESGLY-NH2[D-ILE2,ILE4]VPSODIUM CHLORIDED(CH2)5[TYR(ME)2,THR4]OVT[VAL4]AVP[3H]SR 121463ANELIVAPTAN[PHE3]OTTHALIDOMIDEHEPARAN SULFATECHONDROITIN SULFATESOPC-21268LIXIVAPTAND[CHA4]AVPD(CH2)5[D-ILE2,ILE4]AVPD(CH2)5[TYR(ME)2,THR4,PHE(3I,4N3)-NH29]OVTDAVPVNA932D(CH2)5[TYR(ET)2,VAL4,DES-GLY9]AVPD[LEU4]AVPRELCOVAPTAND[PEN1,TYR(ME)2]AVPBALOVAPTANDOCETAXEL ANHYDROUSATOSIBAND(CH2)5[D-ILE2,ILE4,TYR-NH29]AVPD(CH2)5[D-ILE2,ILE4,ALA-NH2]AVP[125I]D(CH2)5[D-TYR(ET)2,ILE4,TYR-NH29]AVP[PHAA1,D-TYR(ET)2,LYS6,DES-GLY9]AVPLIT-001DVDAVPSATAVAPTANYM 218[125I]D(CH2)5[D-TYR(ET)2,VAL4,TYR-NH29]AVPRWJ-351647[TBAA1,D-TYR(ET)2,VAL4,LYS6,ARG-NH28,DES-GLY9]AVP[PHAA1,D-TYR(ME)2,ARG6,TYR-NH29]AVP
Supporting Publications7
| PMID | Title | Abstract |
|---|---|---|
| 34265469 | Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer. | Furthermore, utilizing quantitative proteomics approach to reveal the proteomes of CD151-deleted exosomes and cells, we found that exosomal CD151 facilitated secretion of ribosomal proteins via exosomes while inhibiting exosome secretion of complement proteins. Moreover, we proved that CD151-deleted exosomes significantly decreased the migration and invasion of TNBC cells. Most importantly, we found that the tetraspanin CD151 expression levels in TNBC-derived serum exosomes were significantly higher than those exosomes from healthy subjects, and we validated our findings with samples from 16 additional donors. This is the first comparative study of the proteomes of TNBC patient-derived and CD151-deleted exosomes. |
| 38037300 | Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles. | No abstract available |
| 38576002 | Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation. | No abstract available |
| 38871114 | Proteomic analysis of endothelial cells and extracellular vesicles in response to indoxyl sulfate: Mechanisms of endothelial dysfunction in chronic kidney disease. | No abstract available |
| 39535266 | Divergent Proteomic Profiles and Uptake Mechanisms of Exosomes Derived from Human Dental Pulp Stem Cells, Endothelial Cells, and Fibroblasts. | No abstract available |
| 39996590 | Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids. | No abstract available |
| 40689422 | Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles. | No abstract available |