Protein detail
MRP6
ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6)
Protein symbol MRP6 | UniProt ID | EVMP score 0.63 |
Frequency 7 | Transmembrane count 17 | Protein classification |
Basic Information
Protein Names
ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6)
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Transporters:Primary Active Transporters
- Disease related genes
Transmembrane
32..52; Helical; Name=1; 73..93; Helical; Name=2; 99..119; Helical; Name=3; 132..149; Helical; Name=4; 168..188; Helical; Name=5; 303..323; Helical; Name=6; 350..370; Helical; Name=7; 427..447; Helical; Name=8; 451..471; Helical; Name=9; 534..554; Helical; Name=10; 576..596; Helical; Name=11; 940..960; Helical; Name=12; 998..1018; Helical; Name=13; 1062..1082; Helical; Name=14; 1084..1104; Helical; Name=15; 1176..1196; Helical; Name=16; 1199..1219; Helical; Name=17
Transmembrane Count
17
Ensembl
Entrez Gene Symbol
Frequency
7
EVMP Score
0.63
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Transporters:Primary Active Transporters
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| basal_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | LOCATE | No | No | No | No | No |
| plasma_membrane | plasma_membrane | LOCATE | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 38321535 |
Sequence, Structure & Domains
Sequences
Length
1,503
Mass
164,906
Sequence
MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O95255-1; Sequence=Displayed; Name=2; Synonyms=URG7; IsoId=O95255-2; Sequence=VSP_047315, VSP_047316; Name=3; Synonyms=Delta19Delta24; IsoId=O95255-3; Sequence=VSP_057077, VSP_057078
Alternative Sequence
75..99; LGFALIVLCTSSVAVALWKIQQGTP -> AAIPGSLEPGNVRGRQGTGWNLVKS (in isoform 2); 100..1503; Missing (in isoform 2); 806..871; TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTST -> KQNLGPAPRTPEAPLQAGGPSLDARGPSSQSLRRTVPLQKPRQRFLWMTLTGQDGQQERTASNTAG (in isoform 3); 872..1503; Missing (in isoform 3)
3D Structural Models
Turn
801..804; 1445..1450
Helix
669..676; 707..712; 719..728; 732..737; 741..743; 755..768; 785..795; 817..819; 837..842; 846..852; 1305..1312; 1330..1332; 1335..1340; 1356..1360; 1368..1377; 1381..1386; 1390..1392; 1404..1417; 1434..1444; 1460..1463; 1483..1488; 1492..1499
Beta Strand
627..639; 645..654; 658..662; 680..689; 693..696; 704..706; 738..740; 745..751; 772..778; 781..783; 805..810; 820..827; 830..835; 1265..1272; 1274..1278; 1281..1289; 1294..1298; 1319..1325; 1342..1345; 1353..1355; 1387..1389; 1421..1426; 1430..1432; 1451..1459; 1464..1473; 1476..1481
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
881..901; Basic and acidic residues
Domain (FT)
311..593; ABC transmembrane type-1 1; 629..853; ABC transporter 1; 947..1228; ABC transmembrane type-1 2; 1265..1499; ABC transporter 2
Region
854..919; Disordered
Protein Families
- ABC transporter superfamily
- ABCC family
- Conjugate transporter (TC 3.A.1.208) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Clinical Relevance
Drugs
TOLVAPTAN[PHAA1,D-TYR(ET)2,VAL4,LYS6,TYR-NH28,DES-GLY9]AVPD(CH2)5[TYR(ME)2,THR4,TYR-NH29]OVTD[VAL4,DARG8]VP[3H]DDAVPDESMOPRESSINOH-LVAARGIPRESSINSKF-105494[PHAA1,D-TYR2,VAL4,ARG6,ARG-NH29]AVPYM 471LVPD(CH2)5[D-ILE2,VAL4,TYR-NH29]AVPMOZAVAPTAND(CH2)5[TYR(ME)2]AVPD(CH2)5[D-ILE2,ILE4,ALA-NH29]AVPCONIVAPTANRO5028442OPC-51803D[D-PAL2]AVPARGIPRESTOCIN[3H]AVP (HUMAN, MOUSE, RAT)D[D-PHE2]AVPD(CH2)5[D-TYR(ET)2,VAL4,TYR-NH29]AVP[3H]DESGLY-NH2[D-ILE2,ILE4]VPSODIUM CHLORIDED(CH2)5[TYR(ME)2,THR4]OVT[VAL4]AVP[3H]SR 121463ANELIVAPTAN[PHE3]OTTHALIDOMIDEHEPARAN SULFATECHONDROITIN SULFATESOPC-21268LIXIVAPTAND[CHA4]AVPD(CH2)5[D-ILE2,ILE4]AVPD(CH2)5[TYR(ME)2,THR4,PHE(3I,4N3)-NH29]OVTDAVPVNA932D(CH2)5[TYR(ET)2,VAL4,DES-GLY9]AVPD[LEU4]AVPRELCOVAPTAND[PEN1,TYR(ME)2]AVPBALOVAPTANDOCETAXEL ANHYDROUSATOSIBAND(CH2)5[D-ILE2,ILE4,TYR-NH29]AVPD(CH2)5[D-ILE2,ILE4,ALA-NH2]AVP[125I]D(CH2)5[D-TYR(ET)2,ILE4,TYR-NH29]AVP[PHAA1,D-TYR(ET)2,LYS6,DES-GLY9]AVPLIT-001DVDAVPSATAVAPTANYM 218[125I]D(CH2)5[D-TYR(ET)2,VAL4,TYR-NH29]AVPRWJ-351647[TBAA1,D-TYR(ET)2,VAL4,LYS6,ARG-NH28,DES-GLY9]AVP[PHAA1,D-TYR(ME)2,ARG6,TYR-NH29]AVP