Protein detail
NPT2B
Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)
Entry name NPT2B | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 8 | Protein classification Cancer-related genesDisease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)
Protein Class (7)
Cancer-related genesDisease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (5)
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Human disease related genes:Respiratory diseases:Lung diseases
- Cancer-related genes
- Disease related genes
Transmembrane
101..121; Helical; Name=M1; 136..156; Helical; Name=M2; 213..233; Helical; Name=M3; 363..383; Helical; Name=M4; 408..428; Helical; Name=M5; 486..506; Helical; Name=M6; 526..546; Helical; Name=M7; 553..573; Helical; Name=M8
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym
NAPI-3B
Gene Description
Solute carrier family 34 member 2
Chromosome
4
Position
25648011-25678748
Supporting publications (n)
1
EVMP confidence score
0.50
Function & Pathway7
Protein Function (5)
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Human disease related genes:Respiratory diseases:Lung diseases
- Cancer-related genes
- Disease related genes
Cellular Component (6)
Molecular Function (4)
Biological Process
KEGG (2)
Reactome (9)
- R-hsa-5687613 diseases associated with surfactant metabolism
- R-hsa-5668914 diseases of metabolism
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9958790 slc mediated transport of inorganic anions
- R-hsa-5619102 slc transporter disorders
- R-hsa-427652 sodium coupled phosphate cotransporters
- R-hsa-5683826 surfactant metabolism
- R-hsa-382551 transport of small molecules
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence24
Ligand-Receptor Signaling (23)
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| slc34 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blottingMORPH | 1 | 32089743 |
Sequence, Structure & Domains9
Sequences
Length
690
Mass
75,759
Sequence
MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=NaPi-3b; IsoId=O95436-1; Sequence=Displayed; Name=2; Synonyms=NaPi-2b, NaPi-IIb; IsoId=O95436-2; Sequence=VSP_016755
Alternative Sequence
38..39; TD -> N (in isoform 2)
Domain & Motif Annotations
Compositional Bias
30..40; Basic and acidic residues
Region
1..42; Disordered
Protein Families
SLC34A transporter family
Sequence Similarities
Belongs to the SLC34A transporter family.
Clinical Relevance5
Disease Involvement (2)
Cancer-related genesDisease variant
Related Diseases (2)
Biomarker
Phase 1/2; Phase 3
Drugs
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |