Protein detail
NPT2B
Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)
Protein symbol NPT2B | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 8 | Protein classification Cancer-related genesDisease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Human disease related genes:Respiratory diseases:Lung diseases
- Cancer-related genes
- Disease related genes
Transmembrane
101..121; Helical; Name=M1; 136..156; Helical; Name=M2; 213..233; Helical; Name=M3; 363..383; Helical; Name=M4; 408..428; Helical; Name=M5; 486..506; Helical; Name=M6; 526..546; Helical; Name=M7; 553..573; Helical; Name=M8
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym
NAPI-3B
Gene Description
Solute carrier family 34 member 2
Chromosome
4
Position
25648011-25678748
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Human disease related genes:Respiratory diseases:Lung diseases
- Cancer-related genes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-5687613 diseases associated with surfactant metabolism
- R-hsa-5668914 diseases of metabolism
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9958790 slc mediated transport of inorganic anions
- R-hsa-5619102 slc transporter disorders
- R-hsa-427652 sodium coupled phosphate cotransporters
- R-hsa-5683826 surfactant metabolism
- R-hsa-382551 transport of small molecules
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | LOCATE | No | No | No | No | No |
| plasma_membrane | plasma_membrane | LOCATE | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blottingMORPH | 1 | 32089743 |
Sequence, Structure & Domains
Sequences
Length
690
Mass
75,759
Sequence
MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=NaPi-3b; IsoId=O95436-1; Sequence=Displayed; Name=2; Synonyms=NaPi-2b, NaPi-IIb; IsoId=O95436-2; Sequence=VSP_016755
Alternative Sequence
38..39; TD -> N (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
30..40; Basic and acidic residues
Region
1..42; Disordered
Protein Families
SLC34A transporter family
Sequence Similarities
Belongs to the SLC34A transporter family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variant
Related Diseases
Biomarker
Phase 1/2; Phase 3
Drugs