Protein detail
VNN1
Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1)
Protein symbol VNN1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1)
Protein Class
EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
Tiff66
Gene Description
Vanin 1
Chromosome
6
Position
132680849-132714055
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificplacentaCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificendothelial cellSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-168249 innate immune system
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-6798695 neutrophil degranulation
- R-hsa-163125 post translational modification synthesis of gpi anchored proteins
- R-hsa-597592 post translational protein modification
- R-hsa-199220 vitamin b5 pantothenate metabolism
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | Yes |
| extracellular | extracellular | OmniPath | No | No | No | No | Yes |
| intracellular | intracellular | GO_Intercell | No | No | No | No | Yes |
| intracellular | intracellular | OmniPath | No | No | No | No | Yes |
| transmembrane | transmembrane | TopDB | No | No | No | No | Yes |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | Yes |
| transmembrane | transmembrane | OmniPath | No | No | No | No | Yes |
| peripheral | peripheral | UniProt_location | No | No | No | No | Yes |
| peripheral | peripheral | OmniPath | No | No | No | No | Yes |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | Yes |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 38207106 |
Sequence, Structure & Domains
Sequences
Length
513
Mass
57,012
Sequence
MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIVCSLSW
3D Structural Models
Turn
79..83; 108..110; 112..115; 217..219; 242..244; 443..445
Helix
46..69; 89..92; 93..95; 102..104; 119..130; 211..215; 220..225; 247..258; 270..272; 318..322; 408..410; 480..482
Beta Strand
24..32; 73..76; 133..144; 156..166; 172..177; 198..201; 204..208; 230..236; 261..267; 277..280; 282..289; 298..307; 332..337; 340..346; 349..358; 361..371; 378..387; 393..402; 404..407; 422..429; 432..434; 436..442; 451..454; 460..465; 470..478
3D Structure
X-ray crystallography (7)
Domain & Motif Annotations
Domain (FT)
39..306; CN hydrolase
Protein Families
- Carbon-nitrogen hydrolase superfamily
- BTD/VNN family
Sequence Similarities
Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.