Protein detail
VNN1
Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1)
Entry name VNN1 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1)
Protein Class (4)
EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
Tiff66
Gene Description
Vanin 1
Chromosome
6
Position
132680849-132714055
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization6
Tissue SpecificplacentaCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificendothelial cellSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway7
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (5)
Molecular Function
Biological Process (3)
Reactome (7)
- R-hsa-168249 innate immune system
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-6798695 neutrophil degranulation
- R-hsa-163125 post translational modification synthesis of gpi anchored proteins
- R-hsa-597592 post translational protein modification
- R-hsa-199220 vitamin b5 pantothenate metabolism
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence18
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | CSPA | No | No | No | No | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | OmniPath | No | No | No | No | Yes |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | Yes |
| cell_surface | cell_surface | OmniPath | No | No | No | No | Yes |
| receptor | receptor | scConnect | No | Yes | No | No | Yes |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 38207106 |
Sequence, Structure & Domains10
Sequences
Length
513
Mass
57,012
Sequence
MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIVCSLSW
3D Structural Models
Turn
79..83; 108..110; 112..115; 217..219; 242..244; 443..445
Helix
46..69; 89..92; 93..95; 102..104; 119..130; 211..215; 220..225; 247..258; 270..272; 318..322; 408..410; 480..482
Beta Strand
24..32; 73..76; 133..144; 156..166; 172..177; 198..201; 204..208; 230..236; 261..267; 277..280; 282..289; 298..307; 332..337; 340..346; 349..358; 361..371; 378..387; 393..402; 404..407; 422..429; 432..434; 436..442; 451..454; 460..465; 470..478
3D Structure
X-ray crystallography (7)
Domain & Motif Annotations
Domain (FT)
39..306; CN hydrolase
Protein Families (2)
- Carbon-nitrogen hydrolase superfamily
- BTD/VNN family
Sequence Similarities
Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |