Protein detail

NPTXR

Neuronal pentraxin receptor

Entry name NPTXR	UniProt ID O95502	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count 1	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Neuronal pentraxin receptor

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Transmembrane

3..23; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000221890

Entrez Gene Symbol

NPTXR

Gene Description

Neuronal pentraxin receptor

Chromosome

Position

38818452-38844028

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function

GO:0046872 metal ion binding

Biological Process (3)

Canonical Pathways (2)

M68 Pid rhoa reg pathway
M186 Pid pdgfrb pathway

Mediation Categories

Other mediation

Relations & Evidence14

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellTalkDB	No	Yes	No	No	No
pentraxin	receptor	OmniPath	No	Yes	No	No	No
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CBX6 NPTXR SFTPC	O95502 O95503 P11686	0:0:0	hu.MAP2
	NPTXR SFTPC	O95502 P11686	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer PrecipitationImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	42	40189497 36064647 38113368 28680152 40465195 34815502 35119778 37322475 35359923 33304478 36497184 34064677 26826536 38895962 31382537 33592500 34473505 38891077 37563857 38917926 32560723 41128489 32916986 41307968 36146834 39223661 33309826 40840701 31805958 33893753 38607062 32230970 38207106 38716512 32835735 34576246 37204515 39001700 37438638 39207047 37926756 41068253

Sequence, Structure & Domains6

Sequences

Length

500

Mass

52,846

Sequence

MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGADNASVASGAAASPGPQRSLSALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLSAAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA

Domain & Motif Annotations

Compositional Bias

42..63; Low complexity

Domain (FT)

292..494; Pentraxin (PTX)

Region

42..81; Disordered; 162..183; Disordered

Clinical Relevance5

Drugs

TROFINETIDE

Antibody

HPA001079

Interaction Protein

ENSG00000106236

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications3

PMID	Title	Abstract
30353492	Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways.	No abstract available
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available