Protein detail
RECK
Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein)
Entry name RECK | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 13 | Transmembrane count | Protein classification Plasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein)
Protein Class (2)
Plasma proteinsPredicted membrane proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
hRECKST15
Gene Description
Reversion inducing cysteine rich protein with kazal motifs
Chromosome
9
Position
36036913-36124455
Supporting publications (n)
13
EVMP confidence score
0.72
Fluorescence & Localization3
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificleukocyte
Function & Pathway6
Cellular Component (5)
Molecular Function (6)
Biological Process (3)
Reactome (2)
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence22
Ligand-Receptor Signaling (20)
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | Yes |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | CSPA | No | No | No | Yes | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | OmniPath | No | No | No | Yes | Yes |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | Yes |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | Yes |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | Yes |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 40326690 |
Sequence, Structure & Domains11
Sequences
Length
971
Mass
106,457
Sequence
MATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTNCREYCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCDRAEDHACQNACKRILMSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVTVHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQEFDRFCEYNPVEVSMLTCLADVREPCQLGCRNLTYCTNFNNRPTELFRSCNAQSDQGAMNDMKLWEKGSIKMPFINIPVLDIKKCQPEMWKAIACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFPEDHTAESICELLSPTDDLKNCIPLDTYLRPSTLGNIVEEVTHPCNPNPCPANELCEVNRKGCPSGDPCLPYFCVQGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLLENCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNLVCSTRLCLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVGLQDHQFEFGSCMSKDPCNPNPCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQDPVCDTDHMEHNNLCTLYQRGKSLSYKGPCQPFCRATEPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPTLASHVPLSALIISQVQVSSSVPSAGVRARPSCHSLLLPLSLGLALHLLWTYN
3D Structural Models
Helix
211..218; 223..235; 239..249; 259..269
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Repeat
37..84; Knot 1; 104..141; Knot 2; 151..197; Knot 3; 216..263; Knot 4; 292..338; Knot 5
Domain (CC)
The Kazal-like domains mediate the serine protease inhibitor activity.
Domain (FT)
627..673; Kazal-like 1; 698..752; Kazal-like 2; 753..789; Kazal-like 3
Region
37..338; 5 X Knot repeats
Protein Families
RECK family
Sequence Similarities
Belongs to the RECK family.
Supporting Publications13
| PMID | Title | Abstract |
|---|---|---|
| 39207047 | The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No abstract available |
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