Protein detail

ADH1B

All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta)

Entry name
ADH1B
UniProt ID
P00325
EVMP confidence score
0.60
Supporting publications (n)
13
Transmembrane count
Protein classification
EnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta)
Protein Class (6)
EnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (5)
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • ENZYME proteins:Oxidoreductases
  • Predicted intracellular proteins
  • Enzymes
  • FDA approved drug targets:Small molecule drugs
Ensembl
ENSG00000196616
Entrez Gene Symbol
ADH1B
Gene Synonym
ADH2
Gene Description
Alcohol dehydrogenase 1B (class I), beta polypeptide
Chromosome
4
Position
99304971-99352760
Supporting publications (n)
13
EVMP confidence score
0.60
Fluorescence & Localization2
Cell SpecificNeutrophilsBlood Cell Specificclassical monocyte
Function & Pathway7
Protein Function (5)
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • ENZYME proteins:Oxidoreductases
  • Predicted intracellular proteins
  • Enzymes
  • FDA approved drug targets:Small molecule drugs
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (9)
Reactome (3)
Mediation Categories (2)
Clinical-translation mediationMetabolism mediation
Relations & Evidence7

Ligand-Receptor Signaling (5)

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ADH1BP003252PDBPDB:1hdzPDB:1hdyPDB:1hszPDB:1dehPDB:1u3vPDB:1htbPDB:1u3uPDB:3hudPDB:1hdx

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyWestern blottingMORPH132089743
Sequence, Structure & Domains11

Sequences

Length
375
Mass
39,835
Sequence
MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICHTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P00325-1; Sequence=Displayed; Name=2; IsoId=P00325-2; Sequence=VSP_054847
Alternative Sequence
1..40; Missing (in isoform 2)

3D Structural Models

Turn
142..144; 186..188; 259..261; 285..287
Helix
48..54; 102..105; 155..157; 167..170; 171..174; 176..185; 203..214; 227..229; 230..235; 244..246; 251..258; 273..282; 307..310; 320..322; 325..337; 344..346; 353..355; 356..364
Beta Strand
8..15; 23..29; 36..45; 56..58; 62..65; 69..77; 89..92; 99..101; 116..119; 131..133; 136..139; 147..154; 158..160; 195..199; 218..223; 239..242; 262..268; 289..292; 302..304; 314..317; 347..352; 369..374
3D Structure
X-ray crystallography (9)

Domain & Motif Annotations

Protein Families
Zinc-containing alcohol dehydrogenase family
Sequence Similarities
Belongs to the zinc-containing alcohol dehydrogenase family.
Clinical Relevance4
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs (3)
FOMEPIZOLENITREFAZOLEACETALDEHYDE
Antibody (2)
HPA047814HPA060902
Supporting Publications13
PMIDTitleAbstract
33592500A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.No abstract available
34576246Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.No abstract available
36064647Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.No abstract available
37204515Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.No abstract available
37322475Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.No abstract available
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No abstract available
38207106Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.No abstract available
39207047The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.No abstract available
40189497Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.No abstract available
40465195Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome.No abstract available
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