Protein detail
ADH1B
All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta)
Entry name ADH1B | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 13 | Transmembrane count | Protein classification EnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
All-trans-retinol dehydrogenase [NAD(+)] ADH1B (EC 1.1.1.105) (Alcohol dehydrogenase 1B) (Alcohol dehydrogenase subunit beta)
Protein Class (6)
EnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (5)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym
ADH2
Gene Description
Alcohol dehydrogenase 1B (class I), beta polypeptide
Chromosome
4
Position
99304971-99352760
Supporting publications (n)
13
EVMP confidence score
0.60
Fluorescence & Localization2
Cell SpecificNeutrophilsBlood Cell Specificclassical monocyte
Function & Pathway7
Protein Function (5)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (9)
- hsa00010 Glycolysis / Gluconeogenesis
- KEGG:hsa00071 Fatty acid degradation
- KEGG:hsa00350 Tyrosine metabolism
- KEGG:hsa00620 Pyruvate metabolism
- KEGG:hsa00830 Retinol metabolism
- KEGG:hsa00980 Metabolism of xenobiotics by cytochrome P450
- KEGG:hsa00982 Drug metabolism - cytochrome P450
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa04936 Alcoholic liver disease
Reactome (3)
Mediation Categories (2)
Clinical-translation mediationMetabolism mediation
Relations & Evidence7
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blottingMORPH | 1 | 32089743 |
Sequence, Structure & Domains11
Sequences
Length
375
Mass
39,835
Sequence
MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICHTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P00325-1; Sequence=Displayed; Name=2; IsoId=P00325-2; Sequence=VSP_054847
Alternative Sequence
1..40; Missing (in isoform 2)
3D Structural Models
Turn
142..144; 186..188; 259..261; 285..287
Helix
48..54; 102..105; 155..157; 167..170; 171..174; 176..185; 203..214; 227..229; 230..235; 244..246; 251..258; 273..282; 307..310; 320..322; 325..337; 344..346; 353..355; 356..364
Beta Strand
8..15; 23..29; 36..45; 56..58; 62..65; 69..77; 89..92; 99..101; 116..119; 131..133; 136..139; 147..154; 158..160; 195..199; 218..223; 239..242; 262..268; 289..292; 302..304; 314..317; 347..352; 369..374
3D Structure
X-ray crystallography (9)
Domain & Motif Annotations
Protein Families
Zinc-containing alcohol dehydrogenase family
Sequence Similarities
Belongs to the zinc-containing alcohol dehydrogenase family.
Clinical Relevance4
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs (3)
Supporting Publications13
| PMID | Title | Abstract |
|---|---|---|
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No abstract available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No abstract available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No abstract available |
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