Protein detail

ADA

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Entry name ADA	UniProt ID P00813	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Protein Class (8)

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000196839

Entrez Gene Symbol

ADA

Gene Synonym

ADA1

Gene Description

Adenosine deaminase

Chromosome

Position

44584896-44652252

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificCytotrophoblasts

Function & Pathway7

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (8)

Molecular Function (5)

Biological Process (3)

KEGG (4)

Reactome (6)

Mediation Categories (6)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence157

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	GO_Intercell	No	Yes	No	No	No
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	DGIdb	No	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADA	P00813	AA1R	P30542	Yes	Yes	No	HPRDSPIKE_LCSIGNOR	HPRD:12150791 HPRD:9247966 SIGNOR:18680557 SPIKE_LC:16713569

Protein Complex Composition (144)

144 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ATXN7L3 ENY2 KAT2A PCID2 SLTM SUPT7L TADA3 TAF10 TP53 TRRAP USP22	O75528 O94864 P04637 Q12962 Q14CW9 Q5JVF3 Q92830 Q9NPA8 Q9NWH9 Q9UPT9 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9023
SGF29 SUPT20H SUPT7L TADA1 TADA2B TADA3 TAF6L	O75528 O94864 Q86TJ2 Q8NEM7 Q96BN2 Q96ES7 Q9Y6J9	0:0:0:0:0:0:0	hu.MAP2
ADAP1 KIF13B	O75689 Q9NQT8	2:2	PDB	PDB:3mdbPDB:3fm8
SUPT7L TADA2B	O94864 Q86TJ2	0:0	hu.MAP2
ADAMTSL1 B3GLCT CFP KIF2C PAPLN SGO1	O95428 P27918 Q5FBB7 Q6Y288 Q8N6G6 Q99661	0:0:0:0:0:0	hu.MAP2
ADAMTSL1 B3GLCT CFP PAPLN	O95428 P27918 Q6Y288 Q8N6G6	0:0:0:0	hu.MAP2
BPNT1 CAB39 CAB39L FDXR MVD NADK2 SDR39U1 STK11 STRADA STRADB TP53I3	O95861 P22570 P53602 Q15831 Q4G0N4 Q53FA7 Q7RTN6 Q9C0K7 Q9H9S4 Q9NRG7 Q9Y376	0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
ADA	P00813	2	PDB	PDB:7rtg
ADA APRT CNBP	P00813 P07741 P62633	0:0:0	hu.MAP
ADA PCK1 PCK2	P00813 P35558 Q16822	0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38037300

Sequence, Structure & Domains10

Sequences

Length

363

Mass

40,764

Sequence

MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL

3D Structural Models

Turn

92..94; 172..176

Helix

18..20; 24..34; 43..50; 58..62; 63..67; 69..72; 76..91; 104..107; 116..118; 126..144; 159..161; 162..171; 191..193; 195..207; 221..229; 240..244; 246..254; 263..268; 279..285; 297..300; 304..315; 319..331; 337..351; 355..362

Beta Strand

11..13; 95..102; 109..111; 147..155; 177..184; 210..219; 234..238; 258..261; 270..272; 290..292; 333..335

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Region

126..143; Required for binding to DDP4

Protein Families (2)

Metallo-dependent hydrolases superfamily
Adenosine and AMP deaminases family

Sequence Similarities

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

Clinical Relevance6

Disease Involvement (4)

Disease variantFDA approved drug targetsHereditary hemolytic anemiaSCID

Related Diseases (6)

Adaptive immunity immunodeficiency Chronic pain Immunodeficiency Malignant haematopoietic neoplasm Mature B-cell leukaemia Multiple sclerosis

Biomarker

Approved; Preregistration; Phase 3

Drug Targets

FDA approved drug targets

Antibody (4)

HPA001399 CAB004307 HPA023884 CAB080432

Supporting Publications1

PMID	Title	Abstract
38892056	ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins.	Basigin is a type 1 integral membrane receptor secreted in exosomes or released by ectodomain shedding from the cell surface.