Protein detail

ADA

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Entry name ADA	UniProt ID P00813	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)

Protein Class

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000196839

Entrez Gene Symbol

ADA

Gene Synonym

ADA1

Gene Description

Adenosine deaminase

Chromosome

Position

44584896-44652252

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificCytotrophoblasts

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	GO_Intercell	No	Yes	No	No	No
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	DGIdb	No	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADA	P00813	AA1R	P30542	Yes	Yes	No	HPRDSPIKE_LCSIGNOR	HPRD:12150791 HPRD:9247966 SIGNOR:18680557 SPIKE_LC:16713569

Protein Complex Composition

144 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ADA PCK2	P00813 Q16822	0:0	hu.MAPhu.MAP2
CCNA2 CCNE1 CDC6 CDK1 CDK2 CDK3 CKS1B CKS2 FTSJ1 THADA UBC	P06493 P0CG48 P20248 P24864 P24941 P33552 P61024 Q00526 Q6YHU6 Q99741 Q9UET6	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6162
CAB39 DMC1 DNAJA3 GPI RAD51 RAD54B STRADA	P06744 Q06609 Q14565 Q7RTN6 Q96EY1 Q9Y376 Q9Y620	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7204
ADAM17 CALR CANX MBL2 P4HA3 P4HB PDIA3	P07237 P11226 P27797 P27824 P30101 P78536 Q7Z4N8	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8714
ADAR HNRNPA0 HNRNPA1 HNRNPA3 ILF3 KHDRBS1 RBM3 SAFB SAFB2 SLTM ZNF326	P09651 P51991 P55265 P98179 Q07666 Q12906 Q13151 Q14151 Q15424 Q5BKZ1 Q9NWH9	0:0:0:0:0:0:0:0:0:0:0	hu.MAP
KAT2A POU3F2 SOX11 TADA1 TAF1 TAF13 TAF2 TAF5 TAF6 TAF7 TAF9 TBP TBPL1 TRRAP UBC	P0CG48 P20226 P20265 P21675 P35716 P49848 P62380 Q15542 Q15543 Q15545 Q16594 Q6P1X5 Q92830 Q96BN2 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4585
CAB39 DMC1 DNAJA3 HSPA1B RAD51 RAD54B STK11 STRADA STRADB	P0DMV9 Q06609 Q14565 Q15831 Q7RTN6 Q96EY1 Q9C0K7 Q9Y376 Q9Y620	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6175
ADAM33 CD1E TMPRSS11B	P15812 Q86T26 Q9BZ11	0:0:0	hu.MAP2
CDC5L CYP3A5 PUF60 RBM39 RNPS1 SNW1 SREK1 SRSF1 SRSF2 SRSF7 TADA2B U2AF1 U2AF2	P20815 P26368 Q01081 Q01130 Q07955 Q13573 Q14498 Q15287 Q16629 Q86TJ2 Q8WXA9 Q99459 Q9UHX1	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5517
ATP6V1C1 CAB39 CAB39L STK11 STRADA STRADB WDR45B	P21283 Q15831 Q5MNZ6 Q7RTN6 Q9C0K7 Q9H9S4 Q9Y376	0:0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38037300

Sequence, Structure & Domains

Sequences

Length

363

Mass

40,764

Sequence

MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL

3D Structural Models

Turn

92..94; 172..176

Helix

18..20; 24..34; 43..50; 58..62; 63..67; 69..72; 76..91; 104..107; 116..118; 126..144; 159..161; 162..171; 191..193; 195..207; 221..229; 240..244; 246..254; 263..268; 279..285; 297..300; 304..315; 319..331; 337..351; 355..362

Beta Strand

11..13; 95..102; 109..111; 147..155; 177..184; 210..219; 234..238; 258..261; 270..272; 290..292; 333..335

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Region

126..143; Required for binding to DDP4

Protein Families

Metallo-dependent hydrolases superfamily
Adenosine and AMP deaminases family

Sequence Similarities

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

Clinical Relevance

Disease Involvement

Disease variantFDA approved drug targetsHereditary hemolytic anemiaSCID

Related Diseases

Adaptive immunity immunodeficiency Chronic pain Immunodeficiency Malignant haematopoietic neoplasm Mature B-cell leukaemia Multiple sclerosis

Biomarker

Approved; Preregistration; Phase 3

Drug Targets

FDA approved drug targets

Antibody

HPA001399 CAB004307 HPA023884 CAB080432