Protein detail
RASN
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Entry name RASN | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteinsRAS pathway related proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Protein Class (7)
Cancer-related genesDisease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteinsRAS pathway related proteins
Protein Function (18)
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Head and neck cancers
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Human disease related genes:Cancers:Skin cancers
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Cancers:Cancers of endocrine organs
- Potential drug targets
- RAS pathway related proteins
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Ensembl
Entrez Gene Symbol
Gene Synonym
N-ras
Gene Description
NRAS proto-oncogene, GTPase
Chromosome
1
Position
114704469-114716771
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization2
Tissue SpecifickidneyCell SpecificProximal tubule cells
Function & Pathway7
Protein Function (18)
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Head and neck cancers
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Human disease related genes:Cancers:Skin cancers
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Cancers:Cancers of endocrine organs
- Potential drug targets
- RAS pathway related proteins
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Cellular Component (8)
Molecular Function (6)
Biological Process (3)
KEGG (81)
- hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa01522 Endocrine resistance
- KEGG:hsa04010 MAPK signaling pathway
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04068 FoxO signaling pathway
- KEGG:hsa04071 Sphingolipid signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
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Reactome (111)
- R-hsa-9028731 activated ntrk2 signals through frs2 and frs3
- R-hsa-9026519 activated ntrk2 signals through ras
- R-hsa-9034864 activated ntrk3 signals through ras
- R-hsa-442755 activation of nmda receptors and postsynaptic events
- R-hsa-1169092 activation of ras in b cells
- R-hsa-1280218 adaptive immune system
- R-hsa-5621575 cd209 dc sign signaling
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-5637810 constitutive signaling by egfrviii
- R-hsa-1236382 constitutive signaling by ligand responsive egfr cancer variants
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Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence39
Enzyme-Mediated Modification (4)
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| NRAS | STK19 | P49842 | S | 89 | phosphorylation | PhosphoSiteSIGNOR | SIGNOR:30712867 |
| NRAS | PTPN11 | Q06124 | Y | 32 | dephosphorylation | SIGNOR | SIGNOR:26617336 |
| NRAS | PTPN11 | Q06124 | Y | 32 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:26617336 |
| NRAS | SRC | P12931 | Y | 32 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network (18)
18 records.
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Protein Complex Composition (7)
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| KRASNRASRAP1GDS1RASGRF2UBCZDHHC9 | O14827P01111P01116P0CG48P52306Q9Y397 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8870 | ||
| ABL1HRASKRASNRASRIN1 | P00519P01111P01112P01116Q13671 | 0:0:0:0:0 | hu.MAP2 | |||
| ABHD5ABL1HRASKRASNRASRIN1 | P00519P01111P01112P01116Q13671Q8WTS1 | 0:0:0:0:0:0 | hu.MAP2 | |||
| NRAS | P01111 | 2 | PDB | PDB:6zizPDB:6wghPDB:8vm2PDB:6zio | ||
| NRASPPIA | P01111P62937 | 2:2 | PDB | PDB:9bg0PDB:9bgdPDB:9bg3PDB:9bg8PDB:8tbi | ||
| ABHD5NRAS | P01111Q8WTS1 | 0:0 | hu.MAP2 | |||
| NRASSHOC2 | P01111Q9UQ13 | 1:1 | PDB | PDB:9btm |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37922300 |
Sequence, Structure & Domains11
Sequences
Length
189
Mass
21,229
Sequence
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM
3D Structural Models
Turn
146..148
Helix
16..25; 62..67; 68..74; 84..86; 88..90; 91..104; 124..137; 152..168
Beta Strand
2..9; 36..46; 49..58; 76..83; 111..116; 141..143
3D Structure
NMR spectroscopy (2); X-ray crystallography (25)
Domain & Motif Annotations
Motif
32..40; Effector region
Region
166..185; Hypervariable region
Protein Families (2)
- Small GTPase superfamily
- Ras family
Sequence Similarities
Belongs to the small GTPase superfamily. Ras family.
Clinical Relevance8
Disease Involvement (3)
Cancer-related genesDisease variantProto-oncogene
Related Diseases (6)
Biomarker
Phase 2; Investigative
Drugs (125)
AZACITIDINECARBOPLATINGANITUMABFUTUXIMAB/MODOTUXIMAB MIXTUREINOSITOLBRAF INHIBITOR BGB-3245NULLSELUMETINIBKO-947NIVOLUMABNAVITOCLAXSOTORASIBAKT INHIBITOR MK2206CCT196969P53-HDM2 INTERACTION INHIBITOR MI-773INFIGRATINIBCETUXIMABTRAMETINIB DIMETHYL SULFOXIDEEXARAFENIBRIBOCICLIBQUIZARTINIBPEMBROLIZUMABVEMURAFENIBDABRAFENIBIPILIMUMABADAVOSERTIBANTI-CD19 CAR T CELLS PREPARATIONAZ628GI-4000GDC-0879MITOGEN-ACTIVATED PROTEIN KINASE KINASE INHIBITORCYTARABINEYM-254890GEDATOLISIBBI-847325TAK-632MEK 1/2 INHIBITOR FCN-159TAK-733EVEROLIMUSE6201IRINOTECAN HYDROCHLORIDEREFAMETINIBOBATOCLAXALPELISIBPANITUMUMABRIGOSERTIBCERITINIBTIZATERKIBHSP90 INHIBITOR XL888ABEMACICLIBTORIPALIMAB-TPZIPF-4708671SALIRASIBALTEPLASEIODINE I 131-6-BETA-IODOMETHYL-19-NORCHOLESTEROLBUPARLISIBOMIPALISIBPLX-4720PIMASERTIBTUNLAMETINIBBELVARAFENIBRUCAPARIBCHELIDONINERINETERKIBFLUOROURACILTEMUTERKIBDUBERMATINIBSORAFENIBFORETINIBSCH772984BIVALENT BRD4 INHIBITOR AZD5153EG5 KINESIN-RELATED MOTOR PROTEIN INHIBITOR 4SC-205RECOMBINANT INTERFERONPELAREOREPNAPORAFENIBTUBASTATIN AERK INHIBITOR CC-90003KRAS G12D INHIBITOR MRTX1133GILTERITINIBCOPANLISIBBI-3406METFORMINCHLOROQUINEDACTOLISIBBINIMETINIBTIVOZANIBCOBIMETINIBULIXERTINIBERK1/2 INHIBITOR ERAS-007LORLATINIBTALAZOPARIBPAZOPANIBREGORAFENIBVENETOCLAXLENVATINIBOLAPARIBMK-8353FF-10101GEMCITABINEB-RAF/VEGFR-2 INHIBITOR RAF265ASTX029GDC-0623OSIMERTINIBMEK INHIBITOR IMM-1-104ENCORAFENIBLIFIRAFENIBI-BET151PALBOCICLIBSINTILIMABDEL-22379LY3009120LEUCOVORIN CALCIUMOPNURASIBMETHYLNITROSOUREATUCATINIBFUTIBATINIBCABOZANTINIB S-MALATECCT241161MIRDAMETINIBSIROLIMUSLYMPHOKINE-ACTIVATED KILLER CELLSCISPLATINICOVAMENIBAVUTOMETINIBPLX8394
Interaction Protein (3)
ENSG00000132155ENSG00000157764ENSG00000174791
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 41063451 | Novel Strategy for Acquiring Metabolically-Tagged Nascent Extracellular Vesicles: Implications for Identifying Surface Protein Markers of Extracellular Vesicles From Neuroblastoma Cells Cultured With Native Serum. | No abstract available |