Protein detail

B3A2

Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2)

Entry name B3A2	UniProt ID P04920	EVMP confidence score 0.88
Supporting publications (n) 23	Transmembrane count 10	Protein classification Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2)

Protein Class (4)

Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Transmembrane

708..731; Helical; 737..774; Helical; 784..816; Helical; 826..847; Helical; 901..918; Helical; 934..954; Helical; 988..1010; Helical; 1036..1059; Helical; 1091..1136; Helical; 1163..1199; Helical

Transmembrane Count

Ensembl

ENSG00000164889

Entrez Gene Symbol

SLC4A2

Gene Synonym (5)

AE2BND3LEPB3L1HKB3NBND3

Gene Description

Solute carrier family 4 member 2

Chromosome

Position

151057210-151076526

Supporting publications (n)

EVMP confidence score

0.88

Fluorescence & Localization4

Tissue Specificbone marrowCell SpecificMyonucleiBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway8

Protein Function (2)

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Cellular Component (5)

Molecular Function (6)

Biological Process (3)

KEGG (4)

Reactome (4)

Canonical Pathways (3)

M3008 Naba ecm glycoproteins
M5884 Naba core matrisome
M5889 Naba matrisome

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationImmune mediation

Relations & Evidence22

Ligand-Receptor Signaling (19)

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
solute_carrier	transporter	Almen2009	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLC4A2	P04920	2	PDB	PDB:8gv9PDB:8jnjPDB:8gvcPDB:8gvhPDB:8gv8PDB:8zlePDB:8gvePDB:8jniPDB:8gvaPDB:8gvf
	SLC4A2 SRARP	P04920 Q8NEQ6	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38083799

Sequence, Structure & Domains13

Sequences

Length

1,241

Mass

137,009

Sequence

MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=A; IsoId=P04920-1; Sequence=Displayed; Name=B1; IsoId=P04920-2; Sequence=VSP_000456; Name=B2; IsoId=P04920-3; Sequence=VSP_045953

Alternative Sequence

1..17; MSSAPRRPAKGADSFCT -> MTQ (in isoform B1); 1..17; MSSAPRRPAKGADSFCT -> MDFLLRPQ (in isoform B2)

3D Structural Models

Turn

355..357; 407..409; 784..786; 1102..1105; 1129..1132; 1141..1143

Helix

371..380; 394..406; 413..415; 416..423; 501..509; 569..579; 583..590; 595..606; 622..640; 683..692; 693..695; 697..701; 702..704; 706..733; 741..757; 769..783; 792..809; 812..818; 821..849; 901..922; 929..936; 939..953; 973..975; 992..996; 998..1019; 1034..1046; 1047..1049; 1058..1065; 1092..1101; 1110..1112; 1115..1128; 1134..1140; 1146..1148; 1153..1156; 1160..1182; 1186..1188; 1189..1194; 1196..1207; 1210..1216; 1233..1235

Beta Strand

322..330; 340..353; 368..370; 384..389; 512..523; 531..541; 544..549; 553..561; 563..566; 610..612; 619..621; 736..738; 898..900; 924..927; 967..969; 982..988; 1022..1024; 1068..1071; 1076..1079; 1083..1085; 1219..1221; 1228..1230

3D Structure

Electron microscopy (10)

Domain & Motif Annotations

Compositional Bias

37..49; Basic and acidic residues; 58..75; Basic and acidic residues; 76..85; Basic residues; 94..110; Basic residues; 120..133; Acidic residues; 141..155; Low complexity; 189..209; Low complexity; 210..219; Gly residues

Region

1..240; Disordered; 288..320; Disordered; 449..471; Disordered; 708..1241; Membrane (anion exchange)

Protein Families

Anion exchanger (TC 2.A.31) family

Sequence Similarities

Belongs to the anion exchanger (TC 2.A.31) family.

Clinical Relevance2

Disease Involvement

Osteopetrosis

Antibody

HPA019339

Supporting Publications23

PMID	Title	Abstract
26801919	Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis.	No abstract available
27723984	Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection.	No abstract available
30071318	Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies.	No abstract available
30451371	Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance.	No abstract available
30760538	Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.	No abstract available
30975894	Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation.	No abstract available
31320591	Exosomes regulate neurogenesis and circuit assembly.	No abstract available
31366407	Proteomic and histopathological characterisation of sicca subjects and primary Sjögren's syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers.	No abstract available
31508500	Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.	No abstract available
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.

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