Protein detail
B3A2
Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2)
Protein symbol B3A2 | UniProt ID | EVMP score 0.88 |
Frequency 23 | Transmembrane count 10 | Protein classification Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Non-erythroid band 3-like protein) (BND3L) (Solute carrier family 4 member 2)
Protein Class
Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Transmembrane
708..731; Helical; 737..774; Helical; 784..816; Helical; 826..847; Helical; 901..918; Helical; 934..954; Helical; 988..1010; Helical; 1036..1059; Helical; 1091..1136; Helical; 1163..1199; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
AE2BND3LEPB3L1HKB3NBND3
Gene Description
Solute carrier family 4 member 2
Chromosome
7
Position
151057210-151076526
Frequency
23
EVMP Score
0.88
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificMyonucleiBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
- M5889 Naba matrisome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38083799 |
Sequence, Structure & Domains
Sequences
Length
1,241
Mass
137,009
Sequence
MSSAPRRPAKGADSFCTPEPESLGPGTPGFPEQEEDELHRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEASEAEGARALTQPSPVSTPSSVQFFLQEDDSADRKAERTSPSSPAPLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRPLPKAQPGHRSYNLQERRRIGSMTGAEQALLPRVPTDEIEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKDFSFPRNISAGSLGSLLGHHHGQGAESDPHVTEPLMGGVPETRLEVERERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPTGAGLEPKSAQDKALLQMVEAAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSIVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEYNEMPMPV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=A; IsoId=P04920-1; Sequence=Displayed; Name=B1; IsoId=P04920-2; Sequence=VSP_000456; Name=B2; IsoId=P04920-3; Sequence=VSP_045953
Alternative Sequence
1..17; MSSAPRRPAKGADSFCT -> MTQ (in isoform B1); 1..17; MSSAPRRPAKGADSFCT -> MDFLLRPQ (in isoform B2)
3D Structural Models
Turn
355..357; 407..409; 784..786; 1102..1105; 1129..1132; 1141..1143
Helix
371..380; 394..406; 413..415; 416..423; 501..509; 569..579; 583..590; 595..606; 622..640; 683..692; 693..695; 697..701; 702..704; 706..733; 741..757; 769..783; 792..809; 812..818; 821..849; 901..922; 929..936; 939..953; 973..975; 992..996; 998..1019; 1034..1046; 1047..1049; 1058..1065; 1092..1101; 1110..1112; 1115..1128; 1134..1140; 1146..1148; 1153..1156; 1160..1182; 1186..1188; 1189..1194; 1196..1207; 1210..1216; 1233..1235
Beta Strand
322..330; 340..353; 368..370; 384..389; 512..523; 531..541; 544..549; 553..561; 563..566; 610..612; 619..621; 736..738; 898..900; 924..927; 967..969; 982..988; 1022..1024; 1068..1071; 1076..1079; 1083..1085; 1219..1221; 1228..1230
3D Structure
Electron microscopy (10)
Domain & Motif Annotations
Compositional Bias
37..49; Basic and acidic residues; 58..75; Basic and acidic residues; 76..85; Basic residues; 94..110; Basic residues; 120..133; Acidic residues; 141..155; Low complexity; 189..209; Low complexity; 210..219; Gly residues
Region
1..240; Disordered; 288..320; Disordered; 449..471; Disordered; 708..1241; Membrane (anion exchange)
Protein Families
Anion exchanger (TC 2.A.31) family
Sequence Similarities
Belongs to the anion exchanger (TC 2.A.31) family.
Clinical Relevance
Disease Involvement
Osteopetrosis
Antibody