Protein detail
GLPC
Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236)
Entry name GLPC | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 11 | Transmembrane count 1 | Protein classification Blood group antigen proteinsCD markersPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236)
Protein Class (3)
Blood group antigen proteinsCD markersPredicted membrane proteins
Protein Function (2)
- Blood group antigen proteins
- CD markers
Transmembrane
58..81; Helical; Signal-anchor for type III membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
CD236CD236RGeGPCGYPD
Gene Description
Glycophorin C (Gerbich blood group)
Chromosome
2
Position
126656133-126696667
Supporting publications (n)
11
EVMP confidence score
0.72
Fluorescence & Localization1
Cell SpecificAlveolar cells type 2
Function & Pathway7
Protein Function (2)
- Blood group antigen proteins
- CD markers
Cellular Component (3)
Molecular Function
Biological Process (3)
KEGG
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence23
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
Sequence, Structure & Domains10
Sequences
Length
128
Mass
13,811
Sequence
MWSTRSPNSTAWPLSLEPDPGMASASTTMHTTTIAEPDPGMSGWPDGRMETSTPTIMDIVVIAGVIAAVAIVLVSLLFVMLRYMYRHKGTYHTNEAKGTEFAESADAALQGDPALQDAGDSSRKEYFI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=Glycophorin-C; IsoId=P04921-1; Sequence=Displayed; Name=Glycophorin-D; IsoId=P04921-2; Sequence=VSP_001777; Name=3; Synonyms=IsoGPC; IsoId=P04921-3; Sequence=VSP_054790
Alternative Sequence
1..21; Missing (in isoform Glycophorin-D); 18..36; Missing (in isoform 3)
3D Structural Models
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
1..12; Polar residues; 22..33; Low complexity
Region
1..48; Disordered; 108..128; Disordered
Protein Families
Glycophorin-C family
Sequence Similarities
Belongs to the glycophorin-C family.
Clinical Relevance2
Drugs (3)