Protein detail

GLPC

Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236)

Protein symbol
GLPC
UniProt ID
EVMP score
0.72
Frequency
11
Transmembrane count
1
Protein classification
Blood group antigen proteinsCD markersPredicted membrane proteins
Basic Information
Protein Names
Glycophorin-C (Glycoconnectin) (Glycophorin-D) (GPD) (Glycoprotein beta) (PAS-2') (Sialoglycoprotein D) (CD antigen CD236)
Protein Class
Blood group antigen proteinsCD markersPredicted membrane proteins
Protein Function
  • Blood group antigen proteins
  • CD markers
Transmembrane
58..81; Helical; Signal-anchor for type III membrane protein
Transmembrane Count
1
Entrez Gene Symbol
Gene Synonym
CD236CD236RGeGPCGYPD
Gene Description
Glycophorin C (Gerbich blood group)
Chromosome
2
Position
126656133-126696667
Frequency
11
EVMP Score
0.72
Fluorescence & Localization
Cell SpecificAlveolar cells type 2
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

22 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATENoNoNoYesNo
intracellularintracellularComPPINoNoNoYesNo
intracellularintracellularGO_IntercellNoNoNoYesNo
intracellularintracellularOmniPathNoNoNoYesNo
transmembranetransmembraneUniProt_locationNoNoNoYesNo
transmembranetransmembraneUniProt_topologyNoNoNoYesNo
transmembranetransmembraneUniProt_keywordNoNoNoYesNo
transmembrane_predictedtransmembraneOmniPathNoNoNoYesNo
transmembranetransmembraneTopDBNoNoNoYesNo
transmembranetransmembraneLOCATENoNoNoYesNo
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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryWestern blotting143219535332013145314852233104892930982971308901572972314333773551227283132538809725544774274196293661390838139054
Sequence, Structure & Domains

Sequences

Length
128
Mass
13,811
Sequence
MWSTRSPNSTAWPLSLEPDPGMASASTTMHTTTIAEPDPGMSGWPDGRMETSTPTIMDIVVIAGVIAAVAIVLVSLLFVMLRYMYRHKGTYHTNEAKGTEFAESADAALQGDPALQDAGDSSRKEYFI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=Glycophorin-C; IsoId=P04921-1; Sequence=Displayed; Name=Glycophorin-D; IsoId=P04921-2; Sequence=VSP_001777; Name=3; Synonyms=IsoGPC; IsoId=P04921-3; Sequence=VSP_054790
Alternative Sequence
1..21; Missing (in isoform Glycophorin-D); 18..36; Missing (in isoform 3)

3D Structural Models

3D Structure
NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias
1..12; Polar residues; 22..33; Low complexity
Region
1..48; Disordered; 108..128; Disordered
Protein Families
Glycophorin-C family
Sequence Similarities
Belongs to the glycophorin-C family.
Clinical Relevance