Protein detail
APOD
Apolipoprotein D (Apo-D) (ApoD)
Protein symbol APOD | UniProt ID | EVMP score 0.50 |
Frequency 7 | Transmembrane count | Protein classification Cancer-related genesCandidate cardiovascular disease genesPlasma proteinsPredicted secreted proteins |
Basic Information
Protein Names
Apolipoprotein D (Apo-D) (ApoD)
Protein Class
Cancer-related genesCandidate cardiovascular disease genesPlasma proteinsPredicted secreted proteins
Protein Function
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
Apo-D
Gene Description
Apolipoprotein D
Chromosome
3
Position
195568705-195584033
Frequency
7
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificadipose tissueBrain Regional Specificbasal gangliaCell SpecificEpicardial cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificintermediate monocyteBlood Lineage Specificmonocytes
Function & Pathway
Protein Function
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-9024446 nr1h2 and nr1h3 mediated signaling
- R-hsa-9029569 nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux
- R-hsa-9006931 signaling by nuclear receptors
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-804914 transport of fatty acids
- R-hsa-382551 transport of small molecules
- R-hsa-425397 transport of vitamins nucleosides and related molecules
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | ELISA | 1 | 26775013 |
Sequence, Structure & Domains
Sequences
Length
189
Mass
21,276
Sequence
MVMLLLLLSALAGLFGAAEGQAFHLGKCPNPPVQENFDVNKYLGRWYEIEKIPTTFENGRCIQANYSLMENGKIKVLNQELRADGTVNQIEGEATPVNLTEPAKLEVKFSWFMPSAPYWILATDYENYALVYSCTCIIQLFHVDFAWILARNPNLPPETVDSLKNILTSNNIDVKKMTVTDQVNCPKLS
3D Structural Models
Helix
39..41; 157..169
Beta Strand
24..27; 44..51; 60..68; 74..81; 87..97; 104..108; 116..123; 125..138; 141..153; 183..185
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Protein Families
- Calycin superfamily
- Lipocalin family
Sequence Similarities
Belongs to the calycin superfamily. Lipocalin family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Antibody